PDF(Pubmed)
Abstract：
UNASSIGNED: This study was designed to prospectively evaluate the feasibility of an opioid-free anesthesia protocol and describe the quality of recovery and management of postoperative analgesia in dogs after a tibial plateau leveling osteotomy (TPLO).
UNASSIGNED: In total, 20 dogs presented for TPLO were included. After premedication with intravenous (IV) medetomidine (0.005-0.007 mg/kg) and midazolam (0.2 mg/kg), the dogs were anesthetized using ketamine (2 mg/kg) and propofol and maintained with isoflurane and ketamine CRI (0.6 mg/kg/h). Sciatic and femoral nerve blocks were performed with bupivacaine 0.5% (0.087 +/- 0.01 and 0.09 +/- 0.02 mL/kg, respectively). Meloxicam (0.2 mg/kg IV) was administered intraoperatively, after osteotomy. Fentanyl (0.002 mg/kg IV) was administered intraoperatively, as rescue analgesia in the case of sustained increase in cardiorespiratory variables. Two pain scores (French 4A-VET and Glasgow short form) were performed at conscious sternal recumbency and 2, 4, 6, 8, 12, and 20 h after extubation and compared to baseline using a Friedman test followed by a Nemenyi post-hoc test. The time taken for the first food intake and urination was reported.
UNASSIGNED: Intraoperative opioid-free anesthesia was feasible in 11 dogs, whereas 9 dogs received fentanyl once during arthrotomy. No opioid postoperative rescue analgesia was required. Food intake occurred within 6 h, and all dogs were discharged after 24 h without any complication.
UNASSIGNED: Total opioid-free postoperative analgesia was achieved in all dogs, with adequate recoveries. Although opioid-free anesthesia was feasible in 55% of the population, a single dose of fentanyl was necessary in 45% of the dogs during arthrotomy.
UNASSIGNED: In total, 20 dogs presented for TPLO were included. After premedication with intravenous (IV) medetomidine (0.005-0.007 mg/kg) and midazolam (0.2 mg/kg), the dogs were anesthetized using ketamine (2 mg/kg) and propofol and maintained with isoflurane and ketamine CRI (0.6 mg/kg/h). Sciatic and femoral nerve blocks were performed with bupivacaine 0.5% (0.087 +/- 0.01 and 0.09 +/- 0.02 mL/kg, respectively). Meloxicam (0.2 mg/kg IV) was administered intraoperatively, after osteotomy. Fentanyl (0.002 mg/kg IV) was administered intraoperatively, as rescue analgesia in the case of sustained increase in cardiorespiratory variables. Two pain scores (French 4A-VET and Glasgow short form) were performed at conscious sternal recumbency and 2, 4, 6, 8, 12, and 20 h after extubation and compared to baseline using a Friedman test followed by a Nemenyi post-hoc test. The time taken for the first food intake and urination was reported.
UNASSIGNED: Intraoperative opioid-free anesthesia was feasible in 11 dogs, whereas 9 dogs received fentanyl once during arthrotomy. No opioid postoperative rescue analgesia was required. Food intake occurred within 6 h, and all dogs were discharged after 24 h without any complication.
UNASSIGNED: Total opioid-free postoperative analgesia was achieved in all dogs, with adequate recoveries. Although opioid-free anesthesia was feasible in 55% of the population, a single dose of fentanyl was necessary in 45% of the dogs during arthrotomy.
摘要：
■本研究旨在前瞻性评估无阿片类药物麻醉方案的可行性，并描述狗在胫骨平台平整截骨术（TPLO）后的恢复质量和术后镇痛管理。
■总共，包括20只为TPLO提供的狗。在静脉注射（IV）美托咪定（0.005-0.007mg/kg）和咪达唑仑（0.2mg/kg）前用药后，使用氯胺酮(2mg/kg)和丙泊酚对犬进行麻醉,并用异氟烷和氯胺酮CRI(0.6mg/kg/h)维持麻醉.坐骨神经和股神经阻滞用0.5%布比卡因(0.087+/-0.01和0.09+/-0.02mL/kg,分别)。术中给予美洛昔康（0.2mg/kgIV），截骨术后。术中给予芬太尼（0.002mg/kgIV），在心肺变量持续增加的情况下作为抢救镇痛。在清醒的胸骨卧位和拔管后2、4、6、8、12和20小时进行了两个疼痛评分（法国4A-VET和格拉斯哥简表），并使用Friedman测试与基线进行比较，然后进行Nemenyi事后测试。报告了第一次食物摄入和排尿所花费的时间。
■术中无阿片类药物麻醉在11只犬中可行，而9只狗在关节切开术期间接受了一次芬太尼。术后无阿片类药物抢救镇痛。食物摄入发生在6小时内，所有犬24h后出院，无任何并发症。
■所有狗均实现了无阿片类药物的术后镇痛，有足够的回收。尽管无阿片类药物麻醉在55%的人群中是可行的，在关节切开术中,45%的犬需要单剂量的芬太尼.
■总共，包括20只为TPLO提供的狗。在静脉注射（IV）美托咪定（0.005-0.007mg/kg）和咪达唑仑（0.2mg/kg）前用药后，使用氯胺酮(2mg/kg)和丙泊酚对犬进行麻醉,并用异氟烷和氯胺酮CRI(0.6mg/kg/h)维持麻醉.坐骨神经和股神经阻滞用0.5%布比卡因(0.087+/-0.01和0.09+/-0.02mL/kg,分别)。术中给予美洛昔康（0.2mg/kgIV），截骨术后。术中给予芬太尼（0.002mg/kgIV），在心肺变量持续增加的情况下作为抢救镇痛。在清醒的胸骨卧位和拔管后2、4、6、8、12和20小时进行了两个疼痛评分（法国4A-VET和格拉斯哥简表），并使用Friedman测试与基线进行比较，然后进行Nemenyi事后测试。报告了第一次食物摄入和排尿所花费的时间。
■术中无阿片类药物麻醉在11只犬中可行，而9只狗在关节切开术期间接受了一次芬太尼。术后无阿片类药物抢救镇痛。食物摄入发生在6小时内，所有犬24h后出院，无任何并发症。
■所有狗均实现了无阿片类药物的术后镇痛，有足够的回收。尽管无阿片类药物麻醉在55%的人群中是可行的，在关节切开术中,45%的犬需要单剂量的芬太尼.
