PDF(Pubmed)
Abstract：
UNASSIGNED: To report a case of a 67-year-old male who was successfully managed over a 7-year period for descemetocele secondary to ocular graft versus host disease (oGVHD) using Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment.
UNASSIGNED: We previously reported on a patient managed with a PROSE device for severe dry eyes secondary to oGVHD, who subsequently developed a central corneal descemetocele. The patient was deemed a poor surgical candidate due to limbal stem cell deficiency secondary to oGVHD. Therefore, we elected to closely monitor the descemetocele as the patient continued PROSE therapy. The patient\'s descemetocele has been managed successfully without perforation throughout a 7-year follow-up period with corrected distance visual acuity remaining stable at 20/50 in the affected eye.
UNASSIGNED: Descemetoceles are an uncommon complication of ocular graft versus host disease. This is the longest published report of a corneal descemetocele managed with PROSE. Our report suggests that in appropriate patients who are at high-risk for post-surgical complications, PROSE in conjunction with other medical management should be considered as an alternative to corneal transplantation.
UNASSIGNED: We previously reported on a patient managed with a PROSE device for severe dry eyes secondary to oGVHD, who subsequently developed a central corneal descemetocele. The patient was deemed a poor surgical candidate due to limbal stem cell deficiency secondary to oGVHD. Therefore, we elected to closely monitor the descemetocele as the patient continued PROSE therapy. The patient\'s descemetocele has been managed successfully without perforation throughout a 7-year follow-up period with corrected distance visual acuity remaining stable at 20/50 in the affected eye.
UNASSIGNED: Descemetoceles are an uncommon complication of ocular graft versus host disease. This is the longest published report of a corneal descemetocele managed with PROSE. Our report suggests that in appropriate patients who are at high-risk for post-surgical complications, PROSE in conjunction with other medical management should be considered as an alternative to corneal transplantation.
摘要：
■报告一例67岁男性，该男性在7年的时间内使用人工眼表生态系统置换（PROSE）治疗成功治疗了眼部移植物抗宿主病（oGVHD）继发的后代囊肿。
■我们先前报道了一名患者使用PROSE设备治疗OGVHD继发的严重干眼，随后发展为中央角膜后胚层囊肿。由于继发于oGVHD的角膜缘干细胞缺乏，该患者被认为是不良的手术候选者。因此,当患者继续PROSE治疗时,我们选择密切监测后代囊肿.在整个7年的随访期间，患者的后代囊肿得到了成功的治疗，没有穿孔，受影响的眼睛的矫正视力保持稳定在20/50。
■脱粒囊肿是眼部移植物抗宿主病的一种罕见并发症。这是用PROSE治疗角膜后代囊肿的最长发表报告。我们的报告表明，在手术后并发症高风险的适当患者中，PROSE与其他医疗管理相结合应被视为角膜移植的替代方法。
■我们先前报道了一名患者使用PROSE设备治疗OGVHD继发的严重干眼，随后发展为中央角膜后胚层囊肿。由于继发于oGVHD的角膜缘干细胞缺乏，该患者被认为是不良的手术候选者。因此,当患者继续PROSE治疗时,我们选择密切监测后代囊肿.在整个7年的随访期间，患者的后代囊肿得到了成功的治疗，没有穿孔，受影响的眼睛的矫正视力保持稳定在20/50。
■脱粒囊肿是眼部移植物抗宿主病的一种罕见并发症。这是用PROSE治疗角膜后代囊肿的最长发表报告。我们的报告表明，在手术后并发症高风险的适当患者中，PROSE与其他医疗管理相结合应被视为角膜移植的替代方法。
