PDF(Pubmed)
Abstract：
UNASSIGNED: Enlarged perivascular spaces in basal ganglia (BG-EPVS) are considered an imaging marker of cerebral small vessel disease (CSVD), but its pathogenesis and pathophysiological process remain unclear. While decreased cerebral perfusion is linked to other CSVD markers, the relationship between BG-EPVS and cerebral perfusion remains ambiguous. This study aimed to explore this association.
UNASSIGNED: Elderly individuals with severe BG-EPVS (n = 77) and age/sex-matched controls (n = 89) underwent head CT perfusion imaging. The cerebral perfusion parameters including mean transit time (MTT), time to maximum (TMAX), cerebral blood flow (CBF), and cerebral blood volume (CBV) were quantitatively measured by symmetric regions of interest plotted in the basal ganglia region. Point-biserial correlation and logistics regression analysis were performed to investigate the association between BG-EPVS and cerebral perfusion.
UNASSIGNED: There were no significant differences in MTT, TMAX, or CBF between BG-EPVS group and control group. CBV was significantly lower in the BG-EPVS group (p = 0.035). Point-biserial correlation analysis showed a negative correlation between BG-EPVS and CBV (r = -0.198, p = 0.011). BG-EPVS group and control group as the dependent variable, binary logistics regression analysis showed that CBV was not an independent risk factor for severe BG-EPVS (p = 0.448). All enrolled patients were divided into four groups according to the interquartile interval of CBV. The ordered logistic regression analysis showed severe BG-EPVS was an independent risk factor for decreased CBV after adjusting for confounding factors (OR = 2.142, 95%CI: 1.211-3.788, p = 0.009).
UNASSIGNED: Severe BG-EPVS is an independent risk factor for decreased CBV in the elderly, however, the formation of BG-EPVS is not solely dependent on changes in CBV in this region. This finding provides information about the pathophysiological consequence caused by severe BG-EPVS.
UNASSIGNED: Elderly individuals with severe BG-EPVS (n = 77) and age/sex-matched controls (n = 89) underwent head CT perfusion imaging. The cerebral perfusion parameters including mean transit time (MTT), time to maximum (TMAX), cerebral blood flow (CBF), and cerebral blood volume (CBV) were quantitatively measured by symmetric regions of interest plotted in the basal ganglia region. Point-biserial correlation and logistics regression analysis were performed to investigate the association between BG-EPVS and cerebral perfusion.
UNASSIGNED: There were no significant differences in MTT, TMAX, or CBF between BG-EPVS group and control group. CBV was significantly lower in the BG-EPVS group (p = 0.035). Point-biserial correlation analysis showed a negative correlation between BG-EPVS and CBV (r = -0.198, p = 0.011). BG-EPVS group and control group as the dependent variable, binary logistics regression analysis showed that CBV was not an independent risk factor for severe BG-EPVS (p = 0.448). All enrolled patients were divided into four groups according to the interquartile interval of CBV. The ordered logistic regression analysis showed severe BG-EPVS was an independent risk factor for decreased CBV after adjusting for confounding factors (OR = 2.142, 95%CI: 1.211-3.788, p = 0.009).
UNASSIGNED: Severe BG-EPVS is an independent risk factor for decreased CBV in the elderly, however, the formation of BG-EPVS is not solely dependent on changes in CBV in this region. This finding provides information about the pathophysiological consequence caused by severe BG-EPVS.
摘要：
■基底神经节血管周围间隙增大（BG-EPVS）被认为是脑小血管病（CSVD）的影像学标志，但其发病机制和病理生理过程尚不清楚。虽然减少的脑灌注与其他CSVD标志物有关，BG-EPVS与脑灌注之间的关系仍然不明确。本研究旨在探讨这种关联。
■患有重度BG-EPVS（n=77）和年龄/性别匹配的对照（n=89）的老年人接受了头部CT灌注成像。脑灌注参数包括平均通过时间(MTT),达到最大值的时间(TMAX)，脑血流量（CBF），和脑血容量（CBV）通过在基底神经节区域绘制的对称感兴趣区域定量测量。进行了点双材料相关性和物流回归分析，以研究BG-EPVS与脑灌注之间的关联。
■MTT没有显著差异，TMAX,BG-EPVS组和对照组之间的CBF。BG-EPVS组CBV显著降低(p=0.035)。点相关分析显示BG-EPVS与CBV呈负相关(r=-0.198,p=0.011)。BG-EPVS组和对照组作为因变量，二元logistic回归分析显示CBV不是重症BG-EPVS的独立危险因素(p=0.448)。根据CBV的四分位数间隔将所有入选患者分为四组。有序logistic回归分析显示，校正混杂因素后，重度BG-EPVS是CBV降低的独立危险因素（OR=2.142，95CI：1.211-3.788，p=0.009）。
■重度BG-EPVS是老年人CBV下降的独立危险因素，然而,BG-EPVS的形成不仅仅依赖于该区域CBV的变化。这一发现提供了有关严重BG-EPVS引起的病理生理后果的信息。
■患有重度BG-EPVS（n=77）和年龄/性别匹配的对照（n=89）的老年人接受了头部CT灌注成像。脑灌注参数包括平均通过时间(MTT),达到最大值的时间(TMAX)，脑血流量（CBF），和脑血容量（CBV）通过在基底神经节区域绘制的对称感兴趣区域定量测量。进行了点双材料相关性和物流回归分析，以研究BG-EPVS与脑灌注之间的关联。
■MTT没有显著差异，TMAX,BG-EPVS组和对照组之间的CBF。BG-EPVS组CBV显著降低(p=0.035)。点相关分析显示BG-EPVS与CBV呈负相关(r=-0.198,p=0.011)。BG-EPVS组和对照组作为因变量，二元logistic回归分析显示CBV不是重症BG-EPVS的独立危险因素(p=0.448)。根据CBV的四分位数间隔将所有入选患者分为四组。有序logistic回归分析显示，校正混杂因素后，重度BG-EPVS是CBV降低的独立危险因素（OR=2.142，95CI：1.211-3.788，p=0.009）。
■重度BG-EPVS是老年人CBV下降的独立危险因素，然而,BG-EPVS的形成不仅仅依赖于该区域CBV的变化。这一发现提供了有关严重BG-EPVS引起的病理生理后果的信息。
