PDF(Pubmed)
Abstract：
UNASSIGNED: The popularity of electronic cigarette (e-cigarette) use continues to rise in the United States. While conventional cigarette smoking is an established risk factor for osteoporosis and osteoporotic fracture, the effects of e-cigarette use on bone health are unknown. We aimed to examine the association between e-cigarette use and fragility fractures.
UNASSIGNED: We pooled 2017-2018 data from the National Health and Nutrition Examination Survey (NHANES). We included men and women with complete information on key variables. E-cigarette use was categorized as either never or ever users. Ever users were further classified as former and current users. Fragility fracture was defined as a composite of self-reported fracture of the hip, spine or wrist which resulted from minimal trauma such as a fall from standing height or less.
UNASSIGNED: Of 5569 participants, there were 4519 (81.2%) never e-cigarette users, 1050 (18.8%) ever e-cigarette users, and 444 (8.0%) with self-reported fragility fracture. In adjusted models, ever e-cigarette users had a 46% higher prevalence of self-reported fragility fractures compared to never users (aPR: 1.46, 95% CI: 1.12, 1.89). We also observed a higher prevalence of fragility fractures among former and current e-cigarette users compared to never users (aPR: 1.89, 95% CI: 1.44, 2.48 and aPR: 1.77, 95% CI: 1.04, 3.02 respectively).
UNASSIGNED: E-cigarette use was associated with a higher prevalence of self-reported fragility fracture. These findings suggest that e-cigarette use may be harmful to bone health. These data highlight the critical need for longitudinal studies exploring the potential effect(s) of e-cigarette use on bone health.
UNASSIGNED: We pooled 2017-2018 data from the National Health and Nutrition Examination Survey (NHANES). We included men and women with complete information on key variables. E-cigarette use was categorized as either never or ever users. Ever users were further classified as former and current users. Fragility fracture was defined as a composite of self-reported fracture of the hip, spine or wrist which resulted from minimal trauma such as a fall from standing height or less.
UNASSIGNED: Of 5569 participants, there were 4519 (81.2%) never e-cigarette users, 1050 (18.8%) ever e-cigarette users, and 444 (8.0%) with self-reported fragility fracture. In adjusted models, ever e-cigarette users had a 46% higher prevalence of self-reported fragility fractures compared to never users (aPR: 1.46, 95% CI: 1.12, 1.89). We also observed a higher prevalence of fragility fractures among former and current e-cigarette users compared to never users (aPR: 1.89, 95% CI: 1.44, 2.48 and aPR: 1.77, 95% CI: 1.04, 3.02 respectively).
UNASSIGNED: E-cigarette use was associated with a higher prevalence of self-reported fragility fracture. These findings suggest that e-cigarette use may be harmful to bone health. These data highlight the critical need for longitudinal studies exploring the potential effect(s) of e-cigarette use on bone health.
摘要：
■在美国，电子烟（电子烟）的使用普及率持续上升。虽然传统吸烟是骨质疏松症和骨质疏松性骨折的既定危险因素，电子烟的使用对骨骼健康的影响是未知的。我们旨在研究电子烟使用与脆性骨折之间的关联。
■我们汇总了国家健康与营养检查调查（NHANES）的2017-2018年数据。我们包括了关于关键变量的完整信息的男性和女性。电子烟的使用被归类为从未使用或从未使用过。曾经的用户被进一步分类为以前的和当前的用户。脆性骨折定义为自报告髋部骨折的复合材料，由于最小的创伤，例如从站立高度或更低的高度跌落而导致的脊柱或手腕。
■在5569名参与者中，有4519名(81.2%)从未使用过电子烟的用户，1050（18.8%）曾经的电子烟用户，自我报告脆性骨折444例（8.0%）。在调整后的模型中，与从未使用过的电子烟使用者相比,曾经使用过的电子烟使用者自我报告的脆性骨折患病率高出46%(aPR:1.46,95%CI:1.12,1.89).我们还观察到，与从未使用过的用户相比，以前和现在的电子烟用户的脆性骨折患病率更高（aPR：1.89，95％CI：1.44，2.48和aPR：1.77，95％CI：1.04，3.02）。
■电子烟的使用与自我报告的脆性骨折的患病率更高相关。这些发现表明，使用电子烟可能对骨骼健康有害。这些数据突出了纵向研究探索电子烟使用对骨骼健康的潜在影响的关键需求。
■我们汇总了国家健康与营养检查调查（NHANES）的2017-2018年数据。我们包括了关于关键变量的完整信息的男性和女性。电子烟的使用被归类为从未使用或从未使用过。曾经的用户被进一步分类为以前的和当前的用户。脆性骨折定义为自报告髋部骨折的复合材料，由于最小的创伤，例如从站立高度或更低的高度跌落而导致的脊柱或手腕。
■在5569名参与者中，有4519名(81.2%)从未使用过电子烟的用户，1050（18.8%）曾经的电子烟用户，自我报告脆性骨折444例（8.0%）。在调整后的模型中，与从未使用过的电子烟使用者相比,曾经使用过的电子烟使用者自我报告的脆性骨折患病率高出46%(aPR:1.46,95%CI:1.12,1.89).我们还观察到，与从未使用过的用户相比，以前和现在的电子烟用户的脆性骨折患病率更高（aPR：1.89，95％CI：1.44，2.48和aPR：1.77，95％CI：1.04，3.02）。
■电子烟的使用与自我报告的脆性骨折的患病率更高相关。这些发现表明，使用电子烟可能对骨骼健康有害。这些数据突出了纵向研究探索电子烟使用对骨骼健康的潜在影响的关键需求。
