PDF(Pubmed)
Abstract：
UNASSIGNED: The incidence of early-onset colorectal cancer (EOCRC) has increased globally since the early 1990s. Comprehensively examining the risk factors would be helpful for risk stratification and the development of personalized colorectal cancer screening strategies.
UNASSIGNED: We performed a prospective study of the Chinese population aged 30-50 years to identify potential risk factors during a median follow-up of 9.1 years. We compared the distribution of demographic characteristics, lifestyle factors, dietary habits, and medical history among 222 EOCRC cases and 87,833 normal controls. Multivariate adjusted Cox hazard models were used for estimating EOCRC risks of each risk factor.
UNASSIGNED: Our final analyses indicated that participants with a higher body mass index (HR, 1.04; 95% CI:1.00,1.08), regular alcohol consumption (HR, 1.69; 95% CI: 1.12, 2.91), higher intake of fish (HR, 1.64; 95% CI: 1.01, 2.67), hypertension (HR, 1.99; 95% CI: 1.04, 3.81), diabetes (HR, 2.20; 95% CI: 1.08, 4.49), and first-degree relatives with cancer (HR, 1.70; 95% CI: 1.23, 2.36) were at higher risk of EOCRC.
UNASSIGNED: We identified several modifiable as well as nonmodifiable risk factors, such as higher BMI, alcohol and fish consumption, hypertension, and diabetes, were associated with EOCRC.
UNASSIGNED: We performed a prospective study of the Chinese population aged 30-50 years to identify potential risk factors during a median follow-up of 9.1 years. We compared the distribution of demographic characteristics, lifestyle factors, dietary habits, and medical history among 222 EOCRC cases and 87,833 normal controls. Multivariate adjusted Cox hazard models were used for estimating EOCRC risks of each risk factor.
UNASSIGNED: Our final analyses indicated that participants with a higher body mass index (HR, 1.04; 95% CI:1.00,1.08), regular alcohol consumption (HR, 1.69; 95% CI: 1.12, 2.91), higher intake of fish (HR, 1.64; 95% CI: 1.01, 2.67), hypertension (HR, 1.99; 95% CI: 1.04, 3.81), diabetes (HR, 2.20; 95% CI: 1.08, 4.49), and first-degree relatives with cancer (HR, 1.70; 95% CI: 1.23, 2.36) were at higher risk of EOCRC.
UNASSIGNED: We identified several modifiable as well as nonmodifiable risk factors, such as higher BMI, alcohol and fish consumption, hypertension, and diabetes, were associated with EOCRC.
摘要：
■自1990年代初以来，早发性结直肠癌（EOCRC）的发病率在全球范围内有所增加。全面检查风险因素有助于风险分层和制定个性化的结直肠癌筛查策略。
■我们对30-50岁的中国人群进行了一项前瞻性研究，以在9.1年的中位随访期间确定潜在的危险因素。我们比较了人口特征的分布，生活方式因素，饮食习惯，222例EOCRC病例和87,833例正常对照者的病史。多变量校正Cox风险模型用于估计每个危险因素的EOCRC风险。
■我们的最终分析表明，体重指数较高的参与者（HR，1.04；95%CI：1.00,1.08），定期饮酒(HR，1.69；95%CI：1.12，2.91），鱼的摄入量较高(HR，1.64；95%CI：1.01，2.67），高血压（HR，1.99；95%CI：1.04，3.81），糖尿病（HR，2.20；95%CI：1.08，4.49），和患有癌症的一级亲属(HR，1.70；95%CI：1.23，2.36）的EOCRC风险较高。
■我们确定了几个可修改和不可修改的风险因素，例如更高的BMI，酒精和鱼类的消费，高血压,糖尿病,与EOCRC有关。
■我们对30-50岁的中国人群进行了一项前瞻性研究，以在9.1年的中位随访期间确定潜在的危险因素。我们比较了人口特征的分布，生活方式因素，饮食习惯，222例EOCRC病例和87,833例正常对照者的病史。多变量校正Cox风险模型用于估计每个危险因素的EOCRC风险。
■我们的最终分析表明，体重指数较高的参与者（HR，1.04；95%CI：1.00,1.08），定期饮酒(HR，1.69；95%CI：1.12，2.91），鱼的摄入量较高(HR，1.64；95%CI：1.01，2.67），高血压（HR，1.99；95%CI：1.04，3.81），糖尿病（HR，2.20；95%CI：1.08，4.49），和患有癌症的一级亲属(HR，1.70；95%CI：1.23，2.36）的EOCRC风险较高。
■我们确定了几个可修改和不可修改的风险因素，例如更高的BMI，酒精和鱼类的消费，高血压,糖尿病,与EOCRC有关。
