PDF(Pubmed)
Abstract：
This report presents two cases of patients with long-standing, treatment-resistant Hailey-Hailey disease (HHD) who experienced significant symptom relief through a combination therapy of oral naltrexone and dupilumab injections. The therapeutic potential of targeting the Th2 pathway and Ca2+ signaling with dupilumab in managing HHD manifestations is highlighted. The findings suggest that Th2 blockade with dupilumab, in conjunction with naltrexone, effectively controls recalcitrant HHD, indicating a role of cytokine response in altering disease pathogenesis. This case contributes to the growing body of literature on biologic treatments for HHD and suggests avenues for further research in HHD management.
摘要：
本报告介绍了两例长期住院的患者，治疗耐药的Hailey-Hailey病（HHD），通过口服纳曲酮和dupilumab注射的联合治疗，症状显着缓解。突出了用dupilumab靶向Th2途径和Ca2+信号传导在管理HHD表现中的治疗潜力。研究结果表明，用dupilumab阻断Th2，与纳曲酮一起使用，有效控制顽固性HHD，表明细胞因子反应在改变疾病发病机制中的作用。此案例有助于有关HHD生物治疗的文献不断增加，并为HHD管理的进一步研究提供了途径。
