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Abstract：
UNASSIGNED: The aim of this study was to evaluate the predictive value of the first postoperative day (POD1) drain fluid amylase in predicting pancreatic fistula formation following pancreaticoduodenectomy (PD).
UNASSIGNED: One-hundred and eighty-five prospective patients undergoing PD between April 2014 and April 2018 were studied retrospectively. Cut-off point to predict the development of POPF was determined by median values for drain fluid amylase of 1883 U/L. Patients were classified into two groups according to POD1 drain fluid amylase values: <1883 U/L (Group 1) and ≥1883 U/L (Group 2). Differences between the groups with clinically relevant POPF and without POPF were evaluated.
UNASSIGNED: The incidence of POPF was 17.2%. POD1 amylase level was the strongest predictor of POPF, with levels of higher than 1883 U/L demonstrating the best accuracy (87.5%), sensitivity (78.1%), specificity (89.5%), positive predictive value (60.9%), and negative predictive value (95.1%). One-hundred and forty-four patients (77.8%) had a POD1 drain amylase level of less than 1883 U/L, and POPF developed in only seven (3.7%) cases, whereas in patients with POD1 drain amylase level of 1883 U/L or higher (n= 41), the POPF rate was 31.4% [OR: 22.24, 95% CI (7.930-62.396), p<0.001].
UNASSIGNED: The cut-off point of POD1 drain fluid amylase level (1883 U/L) might predict the clinically relevant POPF with adequate sensitivity and specificity rates in patients undergoing pancreatic resection.
UNASSIGNED: One-hundred and eighty-five prospective patients undergoing PD between April 2014 and April 2018 were studied retrospectively. Cut-off point to predict the development of POPF was determined by median values for drain fluid amylase of 1883 U/L. Patients were classified into two groups according to POD1 drain fluid amylase values: <1883 U/L (Group 1) and ≥1883 U/L (Group 2). Differences between the groups with clinically relevant POPF and without POPF were evaluated.
UNASSIGNED: The incidence of POPF was 17.2%. POD1 amylase level was the strongest predictor of POPF, with levels of higher than 1883 U/L demonstrating the best accuracy (87.5%), sensitivity (78.1%), specificity (89.5%), positive predictive value (60.9%), and negative predictive value (95.1%). One-hundred and forty-four patients (77.8%) had a POD1 drain amylase level of less than 1883 U/L, and POPF developed in only seven (3.7%) cases, whereas in patients with POD1 drain amylase level of 1883 U/L or higher (n= 41), the POPF rate was 31.4% [OR: 22.24, 95% CI (7.930-62.396), p<0.001].
UNASSIGNED: The cut-off point of POD1 drain fluid amylase level (1883 U/L) might predict the clinically relevant POPF with adequate sensitivity and specificity rates in patients undergoing pancreatic resection.
摘要：
■这项研究的目的是评估术后第一天（POD1）引流液淀粉酶在预测胰十二指肠切除术（PD）后胰瘘形成中的预测价值。
■回顾性研究了2014年4月至2018年4月期间接受PD的125名前瞻性患者。预测POPF发展的截止点由1883U/L的排水液淀粉酶的中值确定。根据POD1引流液淀粉酶值将患者分为两组：<1883U/L（第1组）和≥1883U/L（第2组）。评估了具有临床相关POPF和不具有POPF的组之间的差异。
■POPF的发生率为17.2%。POD1淀粉酶水平是POPF的最强预测因子,水平高于1883U/L，显示最佳精度(87.5%)，灵敏度（78.1%），特异性（89.5%），阳性预测值（60.9%），阴性预测值(95.1%)。44名患者（77.8％）的POD1排出淀粉酶水平低于1883U/L，和POPF仅在7例(3.7%)中发展，而在POD1引流淀粉酶水平为1883U/L或更高(n=41)的患者中，POPF率为31.4%[OR：22.24，95%CI（7.930-62.396），p<0.001]。
■POD1引流液淀粉酶水平的截止点（1883U/L）可以预测胰腺切除术患者的临床相关POPF，并具有足够的敏感性和特异性。
■回顾性研究了2014年4月至2018年4月期间接受PD的125名前瞻性患者。预测POPF发展的截止点由1883U/L的排水液淀粉酶的中值确定。根据POD1引流液淀粉酶值将患者分为两组：<1883U/L（第1组）和≥1883U/L（第2组）。评估了具有临床相关POPF和不具有POPF的组之间的差异。
■POPF的发生率为17.2%。POD1淀粉酶水平是POPF的最强预测因子,水平高于1883U/L，显示最佳精度(87.5%)，灵敏度（78.1%），特异性（89.5%），阳性预测值（60.9%），阴性预测值(95.1%)。44名患者（77.8％）的POD1排出淀粉酶水平低于1883U/L，和POPF仅在7例(3.7%)中发展，而在POD1引流淀粉酶水平为1883U/L或更高(n=41)的患者中，POPF率为31.4%[OR：22.24，95%CI（7.930-62.396），p<0.001]。
■POD1引流液淀粉酶水平的截止点（1883U/L）可以预测胰腺切除术患者的临床相关POPF，并具有足够的敏感性和特异性。
