PDF(Pubmed)
Abstract：
Human papillomavirus (HPV) vaccination represents a milestone in primary prevention of sexually transmitted infections. However, little is known about its possible effects on already established HPV infections. We report the case of a 9-year-old immunosuppressed girl with refractory warts, successfully treated with the nonavalent-HPV vaccine and review the literature about the therapeutic effects of HPV vaccination on benign HPV-induced epithelial proliferations in immunocompetent and immunosuppressed patients. In the literature, promising results were shown on cutaneous warts after HPV vaccination, especially in children and young adults, also in immunosuppressed patients, whereas controverse results were found on anogenital warts. These findings suggest a critical need for randomized clinical trials to assess the efficacy of HPV vaccination in the treatment of benign HPV-induced epithelial proliferations.
摘要：
人乳头瘤病毒（HPV）疫苗接种代表了性传播感染一级预防的里程碑。然而,对其对已经确定的HPV感染的可能影响知之甚少。我们报道了一个9岁免疫抑制女孩患有难治性疣的病例，成功使用非单价HPV疫苗治疗，并回顾了HPV疫苗对免疫活性和免疫抑制患者中良性HPV诱导的上皮增殖的治疗作用的文献。在文学中,在HPV疫苗接种后的皮肤疣上显示了有希望的结果，尤其是儿童和年轻人，在免疫抑制患者中，而在肛门生殖器疣上发现了有争议的结果。这些发现表明，迫切需要随机临床试验来评估HPV疫苗接种在良性HPV诱导的上皮增殖治疗中的功效。
