PDF(Pubmed)
Abstract：
Sleep is crucial for wellness, and emerging research reveals a profound connection to gut microbiota. This review explores the bidirectional relationship between gut microbiota and sleep, exploring the mechanisms involved and the therapeutic opportunities it presents. The gut-brain axis serves as a conduit for the crosstalk between gut microbiota and the central nervous system, with dysbiosis in the microbiota impairing sleep quality and vice versa. Diet, circadian rhythms, and immune modulation all play a part. Specific gut bacteria, like Lactobacillus and Bifidobacterium, enhance sleep through serotonin and gamma-aminobutyric acid production, exemplifying direct microbiome influence. Conversely, sleep deprivation reduces beneficial bacteria, exacerbating dysbiosis. Probiotics, prebiotics, postbiotics, and fecal transplants show therapeutic potential, backed by animal and human research, yet require further study on safety and long-term effects. Unraveling this intricate link paves the way for tailored sleep therapies, utilizing microbiome manipulation to improve sleep and health. Accelerated research is essential to fully tap into this promising field for sleep disorder management.
摘要：
睡眠对健康至关重要，新兴的研究揭示了与肠道微生物群的深刻联系。这篇综述探讨了肠道菌群与睡眠之间的双向关系，探索所涉及的机制及其提供的治疗机会。肠-脑轴是肠道微生物群和中枢神经系统之间串扰的管道，微生物群的生态失调会损害睡眠质量，反之亦然。饮食,昼夜节律,和免疫调节都起作用。特定的肠道细菌，比如乳酸菌和双歧杆菌，通过5-羟色胺和γ-氨基丁酸的产生增强睡眠，举例说明直接的微生物组影响。相反，睡眠不足会减少有益细菌，加剧生态失调。益生菌,益生元,postbiotics,粪便移植显示出治疗潜力，在动物和人类研究的支持下，但需要进一步研究安全性和长期效果。解开这个复杂的链接为量身定制的睡眠疗法铺平了道路，利用微生物组操纵来改善睡眠和健康。加速研究对于充分挖掘睡眠障碍管理这个有前途的领域至关重要。
