PDF(Pubmed)
Abstract：
UNASSIGNED: Cervical cancer is one of the most common gynecological malignancies worldwide. The incidence of cervical cancer ranks second for female malignancies in China. However, human papillomavirus (HPV) prevalence and genotype replacement for a long time in Beijing were not yet evaluated.
UNASSIGNED: Women patients who visited clinical departments, especially the gynecology department, were included in this study from 2014 to 2020. They suffered from different kinds of cervical abnormalities even cervical cancer. Thirteen types of HPV were detected in cervical samples by using multiple fluorescence polymerase chain reactions. All patients were divided into four groups according to age (15-30, 31-45, 46-60, and >60 years old).
UNASSIGNED: The study included data from four certain years (2014, 2016, 2018, and 2020). Overall HPV prevalence was 18.0%, 16.7%, 21.9%, and 19.1%, respectively. Of the 13 genotypes, the top one infection type was HPV52, followed by HPV58 and HPV16 or HPV16 and HPV58 in different years. HPV56 prevalence raised from 2018, which replaced HPV39 into the top five list. Only HPV prevalence of 46-60 years age group declined, mainly resulting from the reduced prevalence of HPV39 and HPV58 (p < 0.001 and p = 0.020). The proportions of HPV dual-infection across the four years varied significantly in statistics (p = 0.001), whereas the most common dual-infection HPV39/68 disappeared after 2018.
UNASSIGNED: The prevalence of two HPV genotypes (HPV39 and HPV58) and dual-infection HPV39/68 showed a declining trend, especially in the 46-60 years age group. The trends need to be observed continuously.
UNASSIGNED: Women patients who visited clinical departments, especially the gynecology department, were included in this study from 2014 to 2020. They suffered from different kinds of cervical abnormalities even cervical cancer. Thirteen types of HPV were detected in cervical samples by using multiple fluorescence polymerase chain reactions. All patients were divided into four groups according to age (15-30, 31-45, 46-60, and >60 years old).
UNASSIGNED: The study included data from four certain years (2014, 2016, 2018, and 2020). Overall HPV prevalence was 18.0%, 16.7%, 21.9%, and 19.1%, respectively. Of the 13 genotypes, the top one infection type was HPV52, followed by HPV58 and HPV16 or HPV16 and HPV58 in different years. HPV56 prevalence raised from 2018, which replaced HPV39 into the top five list. Only HPV prevalence of 46-60 years age group declined, mainly resulting from the reduced prevalence of HPV39 and HPV58 (p < 0.001 and p = 0.020). The proportions of HPV dual-infection across the four years varied significantly in statistics (p = 0.001), whereas the most common dual-infection HPV39/68 disappeared after 2018.
UNASSIGNED: The prevalence of two HPV genotypes (HPV39 and HPV58) and dual-infection HPV39/68 showed a declining trend, especially in the 46-60 years age group. The trends need to be observed continuously.
摘要：
■宫颈癌是全球最常见的妇科恶性肿瘤之一。宫颈癌的发病率在中国女性恶性肿瘤中排名第二。然而,北京的人乳头瘤病毒（HPV）流行率和基因型替代率尚未评估。
■到临床科室就诊的女性患者，尤其是妇科,从2014年到2020年被纳入这项研究。他们患有不同类型的宫颈异常甚至宫颈癌。通过使用多重荧光聚合酶链反应在宫颈样本中检测到13种HPV。根据年龄将所有患者分为四组（15-30、31-45、46-60和>60岁）。
■该研究包括来自四个特定年份（2014年，2016年，2018年和2020年）的数据。HPV总体患病率为18.0%，16.7%,21.9%,19.1%，分别。在13种基因型中，在不同年份，感染类型最高的是HPV52，其次是HPV58和HPV16或HPV16和HPV58。HPV56患病率从2018年开始上升，取代HPV39进入前五名。只有46-60岁年龄组的HPV患病率下降，主要是由于HPV39和HPV58的患病率降低（p<0.001和p=0.020）。在过去的四年中，HPV双重感染的比例在统计学上差异显着（p=0.001）。而最常见的双重感染HPV39/68在2018年后消失。
■两种HPV基因型（HPV39和HPV58）和双重感染HPV39/68的患病率呈下降趋势，尤其是在46-60岁年龄段。趋势需要不断观察。
■到临床科室就诊的女性患者，尤其是妇科,从2014年到2020年被纳入这项研究。他们患有不同类型的宫颈异常甚至宫颈癌。通过使用多重荧光聚合酶链反应在宫颈样本中检测到13种HPV。根据年龄将所有患者分为四组（15-30、31-45、46-60和>60岁）。
■该研究包括来自四个特定年份（2014年，2016年，2018年和2020年）的数据。HPV总体患病率为18.0%，16.7%,21.9%,19.1%，分别。在13种基因型中，在不同年份，感染类型最高的是HPV52，其次是HPV58和HPV16或HPV16和HPV58。HPV56患病率从2018年开始上升，取代HPV39进入前五名。只有46-60岁年龄组的HPV患病率下降，主要是由于HPV39和HPV58的患病率降低（p<0.001和p=0.020）。在过去的四年中，HPV双重感染的比例在统计学上差异显着（p=0.001）。而最常见的双重感染HPV39/68在2018年后消失。
■两种HPV基因型（HPV39和HPV58）和双重感染HPV39/68的患病率呈下降趋势，尤其是在46-60岁年龄段。趋势需要不断观察。
