METHODS: We analyzed the National Inpatient Sample (NIS) database to compare the post-PCI bleeding rates for ACKD (CKD stage 3 and above) undergoing PCI between 2006 and 2011 to those without ACKD in patients over the age of 40. Specific ICD-9 CM codes were used to identify these patients.
RESULTS: A total of 49,192 patients had post-PCI bleeding during the study period of which 3,675 (7.5%) had ACKD. Patients with ACKD were older (68.7±11.7 years). During the study period, there was a decline in post-PCI bleeding rates in both ACKD and control groups. Patients with ACKD have significantly higher post-PCI bleeding rates compared to the control group. For example, in 2006, 133.9 in patients with ACKD had bleeding vs. 104.4 per 100,000 in patients without ACKD (P<0.05). After multivariate adjustment for bassline comorbidities, ACKD remained independently associated with post-PCI bleeding risk (OR: 1.07, CI: 1.03-1.11, P<0.001).
CONCLUSIONS: Despite the overall decline in post-PCI bleeding in patients undergoing PCI, ACKD remains independently associated with post-procedural bleeding.
方法:我们分析了国家住院患者样本(NIS)数据库,以比较2006年至2011年间接受PCI的ACKD(CKD3期及以上)与未接受ACKD的患者的PCI后出血率。使用特定的ICD-9CM代码来识别这些患者。
结果:在研究期间,共有49,192例患者出现PCI术后出血,其中3,675例(7.5%)出现ACKD。ACKD患者年龄较大(68.7±11.7岁)。在学习期间,ACKD组和对照组的PCI术后出血率都有所下降.ACKD患者PCI术后出血率明显高于对照组。例如,2006年,ACKD患者中有133.9例出血与没有ACKD的患者为104.4/100,000(P<0.05)。在对巴斯线合并症进行多变量调整后,ACKD与PCI术后出血风险独立相关(OR:1.07,CI:1.03-1.11,P<0.001)。
结论:尽管PCI术后出血总体下降,但ACKD仍与术后出血独立相关。