UNASSIGNED: This article reviews current and emerging pharmacologic, surgical, and neuromodulation therapies for the management of FC in pediatric patients. Efficacy and safety data regarding each of these modalities was reviewed and discussed.
UNASSIGNED: Advancements in therapeutics available for the management of FC necessitate further investigation on safety and efficacy in pediatric populations. Careful consideration should be taken in choosing an available treatment with limited pediatric evidence as adult and pediatric FC have different underlying pathophysiology and require a different therapeutic approach. Standardization of methodology and pediatric endpoints are needed to optimize ability to compare efficacy of different treatments. We predict the future of pediatric FC management will include a personalized approach to care, resulting in improved outcomes.
■本文回顾了当前和新兴的药理学,手术和神经调节疗法用于儿科患者FC的管理。回顾并讨论了每种模式的疗效和安全性数据。
■可用于FC管理的治疗方法的进步需要进一步研究儿科人群的安全性和有效性。由于成人和小儿FC具有不同的潜在病理生理学并且需要不同的治疗方法,因此在选择儿科证据有限的可用治疗方法时应仔细考虑。需要方法学和儿科终点的标准化以优化比较不同治疗的功效的能力。我们预测儿科FC管理的未来将包括个性化的护理方法,从而改善结果。