METHODS: This case involved a 39-year-old male with a history of AS for 11 years, who developed AL (T11/12) in the thoracic vertebrae. After sufficient preoperative preparation, we successfully performed one-stage posterior approach corrective surgery and collected bone biopsies samples for examination. Cultured bacteria were not found, and pathological histology indicated infiltration of inflammatory cells. However, it is worth noting that we discovered a gram-negative bacterium, the Ewingella americana, through mNGS testing. Further histopathological examination suggests chronic inflammatory cell infiltration. After one-stage posterior approach corrective surgery, the patient\'s condition significantly improved. At the 6-month follow-up, the pain significantly decreased, and the patient returned to normal life.
CONCLUSIONS: We detected Ewinia americana in the bone biopsies of Andersson lesion (AL) in ankylosing spondylitis patient by mNGS.
方法:该病例涉及一名39岁男性,有11年AS病史,在胸椎发展AL(T11/12)。经过充分的术前准备,我们成功地进行了一期后路矫正手术,并收集了骨活检样本进行检查.没有发现培养的细菌,病理组织学提示炎性细胞浸润。然而,值得注意的是,我们发现了一种革兰氏阴性细菌,美洲Ewingella,通过MNGS测试。进一步的组织病理学检查提示慢性炎症细胞浸润。一期后路矫正手术后,患者的病情明显改善。在6个月的随访中,疼痛明显减轻,病人恢复正常生活.
结论:我们通过mNGS在强直性脊柱炎患者Andersson病变(AL)的骨活检中检测到了美洲莫西氏菌。