Abstract：
Adult blood cells are produced in the bone marrow by hematopoietic stem cells (HSCs), the origin of which can be traced back to fetal developmental stages. Indeed, during mouse development, at days 10-11 of gestation, the aorta-gonad-mesonephros (AGM) region is a primary site of HSC production, with characteristic cell clusters related to stem cell genesis observed in the dorsal aorta. Similar clusters linked with hematopoiesis are also observed in the other sites such as the yolk sac and placenta. In this review, I outline the formation and function of these clusters, focusing on the well-characterized intra-aortic hematopoietic clusters (IAHCs).
摘要：
成人血细胞是由造血干细胞（HSC）在骨髓中产生的，其起源可以追溯到胎儿发育阶段。的确,在小鼠发育过程中，在妊娠的第10-11天，主动脉-性腺-中肾（AGM）区域是HSC产生的主要部位，在背主动脉中观察到与干细胞发生相关的特征性细胞簇。在其他部位如卵黄囊和胎盘中也观察到与造血相关的类似簇。在这次审查中,我概述了这些集群的形成和功能，重点关注特征良好的主动脉内造血簇（IAHC）。
