Abstract：
Hyaluronic acid (HA) based nanogels showed effective intracellular delivery efficacy for anti-cancer and anti-inflammatory drugs, characterized by their ability targeting relevant cell receptors. In the present study, we demonstrate the ability of hyaluronic acid-polyethyleneimine (HA-PEI) nanogels as a promising dual-functional interfacial active for intra-articular injection to intervene arthritis. Nanomechanical measurements on both model substrates and human cartilage samples confirm that the HA-PEI nanogels can significantly improve interfacial lubrication, in comparison to HA molecules, or silica-based nanoparticles. We show that the Coefficient of Friction significantly decreases with a decreasing nanogel size. The exceptional lubricating performance, coupled with the proven drug delivery capability, evidences the great potential of nanoscopic hydrogels for early-stage arthritis treatment. The flexibility in choosing the chemical nature, molecular architecture, and structural characteristics of nanogels makes it possible to modulate both drug delivery kinetics and interfacial lubrication, thus representing an innovative approach to treat degenerative joint diseases.
摘要：
基于透明质酸（HA）的纳米凝胶对抗癌和抗炎药物显示出有效的细胞内递送功效，以它们靶向相关细胞受体的能力为特征。在本研究中,我们证明了透明质酸-聚乙烯亚胺(HA-PEI)纳米凝胶作为一种有前景的双功能界面活性物质用于关节内注射干预关节炎的能力.模型基底和人软骨样品的纳米力学测量证实，HA-PEI纳米凝胶可以显着改善界面润滑，与HA分子相比，或基于二氧化硅的纳米颗粒。我们表明，摩擦系数随着纳米凝胶尺寸的减小而显着降低。卓越的润滑性能，再加上成熟的药物输送能力，证明了纳米水凝胶在早期关节炎治疗中的巨大潜力。选择化学性质的灵活性，分子结构,和纳米凝胶的结构特征使得可以调节药物递送动力学和界面润滑，因此代表了一种治疗退行性关节疾病的创新方法。
