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Abstract：
Chronic placental inflammation is a routinely diagnosed group of placental lesions that reflect immunologic dysfunction of the mother, fetus, or both.
Complete placental pathology examinations were performed for all term births at New York Presbyterian- Brooklyn Methodist Hospital from January 2010-August 2016. Diagnoses were blinded except to gestational age. CPI lesions were marked as chronic choriodeciduitis, decidual plasma cells, chronic inflammation of basal plate with anchoring villitis, and chronic villitis.
In this cohort of term pregnancies, 257 (11.6 %) males and 218 (9.8 %) females had ≥1 CPI lesions. Chronic villitis was the most common (319 or 14 %), with chronic choriodeciduitis, decidual plasma cells, and chronic inflammation of basal plate with anchoring villitis in 94 (4 %), 69 (3 %) and 170 (8 %), respectively. In males, chronic villitis was associated with lower gestational adjusted birthweight and had no association with placental weight. In females, chronic villitis was associated with lower gestational adjusted birthweight, but the effect became nonsignificant after adjustment for placental weight.
In summary, CPI lesions\' incidence and association with birth weight vary by sex. Chronic villitis is associated with lower birthweight in females; this effect is completely mediated by placental weight. Chronic villitis showed a weak direct association of chronic villitis in males, but no association with lower placental weight in males. We suggest that differences between our results and previous publications reflect effects of sampling bias.
Complete placental pathology examinations were performed for all term births at New York Presbyterian- Brooklyn Methodist Hospital from January 2010-August 2016. Diagnoses were blinded except to gestational age. CPI lesions were marked as chronic choriodeciduitis, decidual plasma cells, chronic inflammation of basal plate with anchoring villitis, and chronic villitis.
In this cohort of term pregnancies, 257 (11.6 %) males and 218 (9.8 %) females had ≥1 CPI lesions. Chronic villitis was the most common (319 or 14 %), with chronic choriodeciduitis, decidual plasma cells, and chronic inflammation of basal plate with anchoring villitis in 94 (4 %), 69 (3 %) and 170 (8 %), respectively. In males, chronic villitis was associated with lower gestational adjusted birthweight and had no association with placental weight. In females, chronic villitis was associated with lower gestational adjusted birthweight, but the effect became nonsignificant after adjustment for placental weight.
In summary, CPI lesions\' incidence and association with birth weight vary by sex. Chronic villitis is associated with lower birthweight in females; this effect is completely mediated by placental weight. Chronic villitis showed a weak direct association of chronic villitis in males, but no association with lower placental weight in males. We suggest that differences between our results and previous publications reflect effects of sampling bias.
摘要：
背景：慢性胎盘炎症是一组常规诊断的胎盘病变，反映了母亲的免疫功能障碍，胎儿,或者两者兼而有之。
方法：2010年1月至2016年8月，在纽约长老会-布鲁克林卫理公会医院对所有足月分娩进行了完整的胎盘病理学检查。除了胎龄外，诊断是盲目的。CPI病变标记为慢性绒毛膜蜕皮炎，蜕膜浆细胞,基底板的慢性炎症与锚定绒毛炎，和慢性绒毛炎。
结果：在足月妊娠队列中，257名（11.6%）男性和218名（9.8%）女性有≥1个CPI病变。慢性绒毛炎是最常见的（319或14%），患有慢性绒毛膜蜕膜炎，蜕膜浆细胞,94例(4%)基底板慢性炎症伴锚定绒毛炎，69（3%）和170（8%），分别。在男性中，慢性绒毛炎与较低的妊娠调整出生体重相关,与胎盘重量无关.在女性中，慢性绒毛炎与较低的妊娠调整出生体重有关，但在调整胎盘重量后效果变得不显著。
结论：总之，CPI病变的发生率和与出生体重的关系因性别而异。慢性绒毛膜炎与女性出生体重较低有关；这种作用完全由胎盘重量介导。慢性绒毛炎在男性中表现出与慢性绒毛炎的微弱直接关联，但与男性胎盘重量较低无关。我们建议我们的结果与以前的出版物之间的差异反映了抽样偏差的影响。
方法：2010年1月至2016年8月，在纽约长老会-布鲁克林卫理公会医院对所有足月分娩进行了完整的胎盘病理学检查。除了胎龄外，诊断是盲目的。CPI病变标记为慢性绒毛膜蜕皮炎，蜕膜浆细胞,基底板的慢性炎症与锚定绒毛炎，和慢性绒毛炎。
结果：在足月妊娠队列中，257名（11.6%）男性和218名（9.8%）女性有≥1个CPI病变。慢性绒毛炎是最常见的（319或14%），患有慢性绒毛膜蜕膜炎，蜕膜浆细胞,94例(4%)基底板慢性炎症伴锚定绒毛炎，69（3%）和170（8%），分别。在男性中，慢性绒毛炎与较低的妊娠调整出生体重相关,与胎盘重量无关.在女性中，慢性绒毛炎与较低的妊娠调整出生体重有关，但在调整胎盘重量后效果变得不显著。
结论：总之，CPI病变的发生率和与出生体重的关系因性别而异。慢性绒毛膜炎与女性出生体重较低有关；这种作用完全由胎盘重量介导。慢性绒毛炎在男性中表现出与慢性绒毛炎的微弱直接关联，但与男性胎盘重量较低无关。我们建议我们的结果与以前的出版物之间的差异反映了抽样偏差的影响。
