Abstract：
Iron ion (Fe3+) detection is crucial for human health since it plays a crucial role in many physiological activities. In this work, a novel Schiff-base functionalized cyanine derivative (CyPy) was synthesized, which was successfully assembled on the surface of upconversion nanoparticles (UCNPs) through an amphiphilic polymer encapsulation method. In the as-designed nanoprobe, CyPy, a recognizer of Fe3+, is served as energy donor and β-NaYF4:Yb,Er upconversion nanoparticles are adopted as energy acceptor. As a result, a 93-fold enhancement of upconversion luminescence is achieved. The efficient energy transfer from CyPy to β-NaYF4:Yb,Er endows the nanoprobe a high sensitivity for Fe3+ in water with a low detection limit of 0.21 μM. Moreover, the nanoprobe has been successfully applied for Fe3+ determination in human serum and tap water samples with recovery ranges of 95 %-105 % and 97 %-106 %, respectively. Moreover, their relative standard deviations are all below 3.72 %. This work provides a sensitive and efficient methodology for Fe3+ detection in clinical and environmental testing.
摘要：
铁离子(Fe3+)检测对人体健康至关重要,因为它在许多生理活动中起着至关重要的作用。在这项工作中,合成了一种新型的席夫碱官能化花青衍生物(CyPy),通过两亲性聚合物封装方法成功组装在上转换纳米颗粒（UCNPs）的表面上。在设计的纳米探针中，CyPy,Fe3+的识别器，作为能量供体和β-NaYF4：Yb，采用Er上转换纳米粒子作为能量受体。因此,实现了93倍的上转换发光增强。从CyPy到β-NaYF4：Yb的有效能量转移，Er赋予纳米探针对水中Fe3的高灵敏度，低检测限为0.21μM。此外，该纳米探针已成功应用于人体血清和自来水样品中Fe3+的测定,回收率分别为95%-105%和97%-106%,分别。此外，它们的相对标准偏差均低于3.72%。这项工作为临床和环境测试中的Fe3检测提供了一种灵敏有效的方法。
