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Abstract：
A transformation is underway in precision and patient-specific medicine. Rapid progress has been enabled by multiple new technologies including induced pluripotent stem cell-derived cardiac myocytes (iPSC-CMs). Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of differentiation into the cardiac lineage, the functional characterization of the resulting cardiac myocytes, and the many applications of in silico models to understand general and patient-specific mechanisms controlling excitation-contraction coupling in health and disease. Furthermore, we explore the current and potential applications of iPSC-CMs in both research and clinical settings, underscoring the far-reaching implications of this rapidly evolving field.
摘要：
精密医学和特定于患者的医学正在发生转变。包括诱导多能干细胞衍生的心肌细胞(iPSC-CM)在内的多种新技术已经实现了快速进展。这里,我们深入研究这些进步和他们未来的承诺，专注于重新编程技术的效率，分化为心脏谱系的保真度，由此产生的心肌细胞的功能特征，以及计算机模型的许多应用，以了解控制健康和疾病中的激发-收缩耦合的一般和患者特定机制。此外，我们探索iPSC-CM在研究和临床环境中的当前和潜在应用，强调了这一迅速发展的领域的深远影响。
