Abstract：
Lubricant-infused slippery surfaces have recently emerged as promising antifouling coatings, showing potential against proteins, cells, and marine mussels. However, a comprehensive understanding of the molecular binding behaviors and interaction strength of foulants to these surfaces is lacking. In this work, mussel-inspired chemistry based on catechol-containing chemicals including 3,4-dihydroxyphenylalanine (DOPA) and polydopamine (PDA) is employed to investigate the antifouling performance and repellence mechanisms of fluorinated-based slippery surface, and the correlated interaction mechanisms are probed using atomic force microscopy (AFM). Intermolecular force measurements and deposition experiments between PDA and the surface reveal the ability of lubricant film to inhibit the contact of PDA particles with the substrate. Moreover, the binding mechanisms and bond dissociation energy between a single DOPA moiety and the lubricant-infused slippery surface are quantitatively investigated employing single-molecule force spectroscopy based on AFM (SM-AFM), which reveal that the infused lubricant layer can remarkably influence the dissociation forces and weaken the binding strength between DOPA and underneath per-fluorinated monolayer surface. This work provides new nanomechanical insights into the fundamental antifouling mechanisms of the lubricant-infused slippery surfaces against mussel-derived adhesive chemicals, with important implications for the design of lubricant-infused materials and other novel antifouling platforms for various bioengineering and engineering applications.
摘要：
注入润滑剂的光滑表面最近已成为有前途的防污涂料，显示出对抗蛋白质的潜力，细胞,和海洋贻贝。然而,缺乏对污染物与这些表面的分子结合行为和相互作用强度的全面了解。在这项工作中,基于含儿茶酚的化学物质（包括3,4-二羟基苯丙氨酸（DOPA）和聚多巴胺（PDA））的贻贝启发化学用于研究基于氟化的光滑表面的防污性能和排斥机制，并使用原子力显微镜（AFM）研究了相关的相互作用机制。分子间力测量和PDA与表面之间的沉积实验揭示了润滑剂膜抑制PDA颗粒与基底接触的能力。此外，使用基于AFM（SM-AFM）的单分子力谱定量研究了单个DOPA部分与注入润滑剂的光滑表面之间的结合机制和键离解能，这表明注入的润滑剂层可以显着影响解离力，并削弱DOPA与全氟化单层表面下方之间的结合强度。这项工作为注入润滑剂的光滑表面对贻贝衍生的粘合剂化学物质的基本防污机理提供了新的纳米力学见解，对于各种生物工程和工程应用的润滑剂注入材料和其他新型防污平台的设计具有重要意义。
