Abstract：
UNASSIGNED: Low-grade gliomas (LGG) are a variety of brain tumors that show different clinical outcomes. The methylation of the GSTM5 gene has been noted in the development of LGG, however, its prognostic importance remains uncertain.
UNASSIGNED: The objective of this study was to examine the correlation between GSTM5 DNA methylation and clinical outcomes in individuals diagnosed with LGG.
UNASSIGNED: Analysis of GSTM5 methylation levels in LGG samples was conducted using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The overall survival based on GSTM5 methylation status was evaluated using Kaplan-Meier curves. The DNA methylation heatmap for particular CpG sites in the GSTM5 gene was visualized using the \"pheatmap\" R package.
UNASSIGNED: The study analyzed that LGG tumors had higher levels of GSTM5 methylation than normal tissues. There was an inverse relationship discovered between GSTM5 expression and methylation. LGG patients with hypermethylation of GSTM5 promoter experienced a positive outcome. Age, grade, and GSTM5 methylation were determined as independent prognostic factors in LGG through both univariate and multivariate Cox regression analyses.
UNASSIGNED: Methylation of GSTM5 DNA, specifically at certain CpG sites, is linked to a positive outlook in patients with LGG. Utilizing the \"pheatmap\" R package to visualize GSTM5 methylation patterns offers important information for identifying prognostic markers and therapeutic targets in low-grade gliomas.
UNASSIGNED: The objective of this study was to examine the correlation between GSTM5 DNA methylation and clinical outcomes in individuals diagnosed with LGG.
UNASSIGNED: Analysis of GSTM5 methylation levels in LGG samples was conducted using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The overall survival based on GSTM5 methylation status was evaluated using Kaplan-Meier curves. The DNA methylation heatmap for particular CpG sites in the GSTM5 gene was visualized using the \"pheatmap\" R package.
UNASSIGNED: The study analyzed that LGG tumors had higher levels of GSTM5 methylation than normal tissues. There was an inverse relationship discovered between GSTM5 expression and methylation. LGG patients with hypermethylation of GSTM5 promoter experienced a positive outcome. Age, grade, and GSTM5 methylation were determined as independent prognostic factors in LGG through both univariate and multivariate Cox regression analyses.
UNASSIGNED: Methylation of GSTM5 DNA, specifically at certain CpG sites, is linked to a positive outlook in patients with LGG. Utilizing the \"pheatmap\" R package to visualize GSTM5 methylation patterns offers important information for identifying prognostic markers and therapeutic targets in low-grade gliomas.
摘要：
■低度神经胶质瘤（LGG）是各种表现出不同临床结果的脑肿瘤。GSTM5基因的甲基化在LGG的发展中已被注意到，然而,其预后重要性仍不确定.
■本研究的目的是检查诊断为LGG的个体中GSTM5DNA甲基化与临床结果之间的相关性。
使用来自癌症基因组图谱(TCGA)和基因表达综合(GEO)数据集的数据进行LGG样品中GSTM5甲基化水平的分析。使用Kaplan-Meier曲线评估基于GSTM5甲基化状态的总生存期。使用“pheatmap”R包可视化GSTM5基因中特定CpG位点的DNA甲基化热图。
■该研究分析了LGG肿瘤的GSTM5甲基化水平高于正常组织。发现GSTM5表达与甲基化之间存在反比关系。具有GSTM5启动子高甲基化的LGG患者经历了阳性结果。年龄,grade,通过单因素和多因素Cox回归分析确定GSTM5甲基化是LGG的独立预后因素。
■GSTM5DNA的甲基化，特别是在某些CpG网站，与LGG患者的积极前景有关。利用“pheatmap”R软件包可视化GSTM5甲基化模式为识别低级别神经胶质瘤的预后标志物和治疗靶标提供了重要信息。
■本研究的目的是检查诊断为LGG的个体中GSTM5DNA甲基化与临床结果之间的相关性。
使用来自癌症基因组图谱(TCGA)和基因表达综合(GEO)数据集的数据进行LGG样品中GSTM5甲基化水平的分析。使用Kaplan-Meier曲线评估基于GSTM5甲基化状态的总生存期。使用“pheatmap”R包可视化GSTM5基因中特定CpG位点的DNA甲基化热图。
■该研究分析了LGG肿瘤的GSTM5甲基化水平高于正常组织。发现GSTM5表达与甲基化之间存在反比关系。具有GSTM5启动子高甲基化的LGG患者经历了阳性结果。年龄,grade,通过单因素和多因素Cox回归分析确定GSTM5甲基化是LGG的独立预后因素。
■GSTM5DNA的甲基化，特别是在某些CpG网站，与LGG患者的积极前景有关。利用“pheatmap”R软件包可视化GSTM5甲基化模式为识别低级别神经胶质瘤的预后标志物和治疗靶标提供了重要信息。
