Abstract：
UNASSIGNED: Information regarding seropositivity and vaccine efficacy among medical students is scarce. This study aims to detect the status of SARS-CoV-2 neutralizing antibodies among the Sinopharm\'s Vero Cell (BBIBP-CorV) vaccinated medical students.
UNASSIGNED: A prospective, cross-sectional study was carried out among medical students of Gandaki Medical College Teaching Hospital, Pokhara, Nepal from March through August 2022. The level of SARS-CoV-2 serum- neutralizing IgG antibody was measured and its relation with participants\' age and sex, duration of vaccination, and any comorbid condition was determined.
UNASSIGNED: A total of 110 medical students were included in the final analysis, the majority being females (65.5%) and the mean age is 23.1 ± 3.2 years. Most of the students (96.4%) had neutralizing antibodies against SARS-CoV-2. Among the 29 (26.36%) students who received a booster dose, the positivity rate was 100%. The mean IgG levels were 9.57 ± 9.58 μg/ml and 2.91 ± 2.47 μg/ml among students receiving an additional booster dose and among those not receiving it, respectively. In the cohort receiving a booster dose of the vaccine, the average value of neutralizing IgG antibodies was high. In contrast, the ones not receiving it, the titers were low and showed a declining trend.
UNASSIGNED: Though the dose strategy of the Sinopharm vaccine is effective, booster vaccination may be an important strategy to ensure protection among medical students, who are at high risk of COVID-19 due to constant patient exposure during their training. Further studies should assess vaccine efficacy among individuals who received other vaccines as well.
UNASSIGNED: A prospective, cross-sectional study was carried out among medical students of Gandaki Medical College Teaching Hospital, Pokhara, Nepal from March through August 2022. The level of SARS-CoV-2 serum- neutralizing IgG antibody was measured and its relation with participants\' age and sex, duration of vaccination, and any comorbid condition was determined.
UNASSIGNED: A total of 110 medical students were included in the final analysis, the majority being females (65.5%) and the mean age is 23.1 ± 3.2 years. Most of the students (96.4%) had neutralizing antibodies against SARS-CoV-2. Among the 29 (26.36%) students who received a booster dose, the positivity rate was 100%. The mean IgG levels were 9.57 ± 9.58 μg/ml and 2.91 ± 2.47 μg/ml among students receiving an additional booster dose and among those not receiving it, respectively. In the cohort receiving a booster dose of the vaccine, the average value of neutralizing IgG antibodies was high. In contrast, the ones not receiving it, the titers were low and showed a declining trend.
UNASSIGNED: Though the dose strategy of the Sinopharm vaccine is effective, booster vaccination may be an important strategy to ensure protection among medical students, who are at high risk of COVID-19 due to constant patient exposure during their training. Further studies should assess vaccine efficacy among individuals who received other vaccines as well.
摘要：
■关于医学生血清阳性和疫苗效力的信息很少。本研究旨在检测接种Sinopharm的Vero细胞（BBIBP-CorV）的医学生中SARS-CoV-2中和抗体的状况。
■预期，在甘达基医学院教学医院的医学生中进行了横断面研究，博卡拉,尼泊尔从2022年3月到8月。测量SARS-CoV-2血清中和IgG抗体水平及其与参与者年龄和性别的关系，疫苗接种持续时间，并确定了任何合并症。
■共有110名医学生被纳入最终分析，大多数为女性（65.5％），平均年龄为23.1±3.2岁。大多数学生（96.4％）具有针对SARS-CoV-2的中和抗体。在29名(26.36%)接受加强剂量的学生中，阳性率为100%。在接受额外加强剂量的学生和未接受加强剂量的学生中，平均IgG水平为9.57±9.58μg/ml和2.91±2.47μg/ml，分别。在接受加强剂量疫苗的队列中，中和IgG抗体的平均值较高.相比之下,那些没有收到它的人，滴度较低，呈下降趋势。
■尽管国药疫苗的剂量策略是有效的，加强疫苗接种可能是确保医学生保护的重要策略，由于患者在训练过程中不断接触COVID-19，这些人处于COVID-19的高风险中。进一步的研究应该评估接种其他疫苗的个体的疫苗效力。
■预期，在甘达基医学院教学医院的医学生中进行了横断面研究，博卡拉,尼泊尔从2022年3月到8月。测量SARS-CoV-2血清中和IgG抗体水平及其与参与者年龄和性别的关系，疫苗接种持续时间，并确定了任何合并症。
■共有110名医学生被纳入最终分析，大多数为女性（65.5％），平均年龄为23.1±3.2岁。大多数学生（96.4％）具有针对SARS-CoV-2的中和抗体。在29名(26.36%)接受加强剂量的学生中，阳性率为100%。在接受额外加强剂量的学生和未接受加强剂量的学生中，平均IgG水平为9.57±9.58μg/ml和2.91±2.47μg/ml，分别。在接受加强剂量疫苗的队列中，中和IgG抗体的平均值较高.相比之下,那些没有收到它的人，滴度较低，呈下降趋势。
■尽管国药疫苗的剂量策略是有效的，加强疫苗接种可能是确保医学生保护的重要策略，由于患者在训练过程中不断接触COVID-19，这些人处于COVID-19的高风险中。进一步的研究应该评估接种其他疫苗的个体的疫苗效力。
