METHODS: This study included a total of 80 periodontitis patients, 40 non-smokers and 40 smokers who were systemically healthy. In this study, patients were divided into 4 groups as follows: Group 1 (Subgingival instrumentation (SI) alone/nonsmoker), Group 2 (SI alone/smoker), Group 3 (SI + Omega-3/nonsmoker) and Group 4 (SI + Omega-3/smoker). Group 3 and 4 consumed 1320 mg Omega-3 capsule (640 mg EPA, 480 mg DHA) once a day for 3 months. Probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI) and bleeding on probing (BOP %) were recorded at baseline, 1 month and 3 months after treatment.
RESULTS: Significant improvement of all clinical parameters at 1 and 3 months was observed in all groups. Whole mouth CAL, GI and BOP% were significantly reduced in group 4 compared to group 2 at 1 and 3 months postoperatively (p < 0.05). For moderately deep pockets (4-6 mm) and deep pockets (7 mm≤), PD and CAL reductions were significantly greater in groups taking omega - 3 (group 3 and group 4) compared to groups not taking omega-3 (group 1 and group 2) between baseline and 1 month and between baseline and 3 months (p ˂ 0.05).
CONCLUSIONS: Omega-3 supplementation given as an adjunct to nonsurgical periodontal treatment provided significant benefit in the improvement of clinical parameters (especially for CAL and PD) in the short term in smokers and non-smokers with periodontitis.
CONCLUSIONS: Nonsurgical periodontal treatment with omega-3 supplementation resulted in significant improvements in clinical parameters in smokers and non-smokers with periodontitis.
方法:本研究共纳入80例牙周炎患者,40名非吸烟者和40名系统健康的吸烟者。在这项研究中,患者分为以下4组:第1组(单用牙龈下器械(SI)/非吸烟者),第2组(单独使用SI/吸烟者),第3组(SI+Omega-3/不吸烟者)和第4组(SI+Omega-3/吸烟者)。第3组和第4组消耗1320毫克Omega-3胶囊(640毫克EPA,480mgDHA)每天一次,连续3个月。探测深度(PD),临床依恋水平(CAL),牙龈指数(GI),基线时记录菌斑指数(PI)和探查出血(BOP%),治疗后1个月和3个月。
结果:在所有组中,在1和3个月时观察到所有临床参数的显着改善。整个口CAL,术后1个月和3个月时,与第2组相比,第4组的GI和BOP%显着降低(p<0.05)。对于中等深度的口袋(4-6mm)和深口袋(7mm≤),在基线和1个月之间以及基线和3个月之间,服用omega-3的组(第3组和第4组)与未服用omega-3的组(第1组和第2组)相比,PD和CAL的减少明显更大(p<0.05)。
结论:Omega-3补充剂作为非手术牙周治疗的辅助治疗,在短期内在改善吸烟者和非吸烟者牙周炎患者的临床参数(尤其是CAL和PD)方面提供了显著的益处。
结论:补充omega-3的非手术牙周治疗可显著改善患有牙周炎的吸烟者和非吸烟者的临床参数。