METHODS: Children with a suspected gastrointestinal motility disorder previously investigated with 24-h 8-lead ADM were reevaluated by applying the 2018 ESPGHAN/NASPGHAN PIPO diagnostic criteria and the 2018 ANMS-NASPGHAN guidelines. ADM findings were compared between children who retrospectively fulfilled a PIPO diagnosis, children who did not, and a control group of healthy adults.
RESULTS: Of 34 children (age 7.9 (±5.1) years, 18 males), 12 retrospectively fulfilled the 2018 PIPO diagnostic criteria. Twenty-five children (10 in the PIPO group) had abnormal diagnostic findings on ADM, whereas 9 (2 in the PIPO group) had no such findings. A PIPO diagnosis implied a significantly higher degree of abnormal ADM patterns (2.33 vs. 1.23, p = 0.02). There were no major differences in quantitative ADM measurements between the groups except higher pressures in children.
CONCLUSIONS: Children who retrospectively fulfilled a PIPO diagnosis had a significantly higher abundance of abnormal ADM findings compared with symptomatic children without PIPO and healthy adults. Our data indicate a need for set criteria for evaluation of ADM in children with suspected PIPO.
方法:通过应用2018年ESPGHAN/NASPGHANPIPO诊断标准和2018年ANMS-NASPGHAN指南,对先前接受24小时8导联ADM调查的疑似胃肠动力障碍儿童进行了重新评估。比较了回顾性诊断为PIPO的儿童的ADM结果,没有的孩子,和健康成年人的对照组。
结果:34名儿童(7.9(±5.1)岁,18名男性),12项回顾性符合2018年PIPO诊断标准。25名儿童(PIPO组10名)在ADM上有异常诊断结果,而9人(PIPO组2人)没有这样的发现。PIPO诊断暗示ADM模式异常程度明显更高(2.33vs.1.23,p=0.02)。除了儿童的压力较高之外,两组之间的ADM定量测量没有重大差异。
结论:与没有PIPO的有症状儿童和健康成人相比,回顾性诊断为PIPO的儿童有明显更多的异常ADM发现。我们的数据表明需要设定标准来评估疑似PIPO儿童的ADM。