Abstract：
BACKGROUND: In 2018 diagnostic criteria for pediatric intestinal pseudo-obstruction (PIPO) were established. Neuromuscular dysfunction of the gastrointestinal tract is one of these, and often examined through antroduodenal manometry (ADM). There is little data on antroduodenal manometries in children. Our objectives were to retrospectively apply these criteria to children evaluated for suspected motility disorder, to reevaluate the ADM patterns and compare children who did and did not meet the PIPO criteria and also with healthy adults.
METHODS: Children with a suspected gastrointestinal motility disorder previously investigated with 24-h 8-lead ADM were reevaluated by applying the 2018 ESPGHAN/NASPGHAN PIPO diagnostic criteria and the 2018 ANMS-NASPGHAN guidelines. ADM findings were compared between children who retrospectively fulfilled a PIPO diagnosis, children who did not, and a control group of healthy adults.
RESULTS: Of 34 children (age 7.9 (±5.1) years, 18 males), 12 retrospectively fulfilled the 2018 PIPO diagnostic criteria. Twenty-five children (10 in the PIPO group) had abnormal diagnostic findings on ADM, whereas 9 (2 in the PIPO group) had no such findings. A PIPO diagnosis implied a significantly higher degree of abnormal ADM patterns (2.33 vs. 1.23, p = 0.02). There were no major differences in quantitative ADM measurements between the groups except higher pressures in children.
CONCLUSIONS: Children who retrospectively fulfilled a PIPO diagnosis had a significantly higher abundance of abnormal ADM findings compared with symptomatic children without PIPO and healthy adults. Our data indicate a need for set criteria for evaluation of ADM in children with suspected PIPO.
METHODS: Children with a suspected gastrointestinal motility disorder previously investigated with 24-h 8-lead ADM were reevaluated by applying the 2018 ESPGHAN/NASPGHAN PIPO diagnostic criteria and the 2018 ANMS-NASPGHAN guidelines. ADM findings were compared between children who retrospectively fulfilled a PIPO diagnosis, children who did not, and a control group of healthy adults.
RESULTS: Of 34 children (age 7.9 (±5.1) years, 18 males), 12 retrospectively fulfilled the 2018 PIPO diagnostic criteria. Twenty-five children (10 in the PIPO group) had abnormal diagnostic findings on ADM, whereas 9 (2 in the PIPO group) had no such findings. A PIPO diagnosis implied a significantly higher degree of abnormal ADM patterns (2.33 vs. 1.23, p = 0.02). There were no major differences in quantitative ADM measurements between the groups except higher pressures in children.
CONCLUSIONS: Children who retrospectively fulfilled a PIPO diagnosis had a significantly higher abundance of abnormal ADM findings compared with symptomatic children without PIPO and healthy adults. Our data indicate a need for set criteria for evaluation of ADM in children with suspected PIPO.
摘要：
背景：2018年建立了小儿假性肠梗阻（PIPO）的诊断标准。胃肠道的神经肌肉功能障碍就是其中之一，经常通过十二指肠测压（ADM）检查。关于儿童十二指肠畸形的数据很少。我们的目标是将这些标准应用于被评估为疑似运动障碍的儿童，重新评估ADM模式，并将符合和不符合PIPO标准的儿童以及健康成人进行比较。
方法：通过应用2018年ESPGHAN/NASPGHANPIPO诊断标准和2018年ANMS-NASPGHAN指南，对先前接受24小时8导联ADM调查的疑似胃肠动力障碍儿童进行了重新评估。比较了回顾性诊断为PIPO的儿童的ADM结果，没有的孩子，和健康成年人的对照组。
结果：34名儿童（7.9（±5.1）岁，18名男性），12项回顾性符合2018年PIPO诊断标准。25名儿童（PIPO组10名）在ADM上有异常诊断结果，而9人(PIPO组2人)没有这样的发现。PIPO诊断暗示ADM模式异常程度明显更高（2.33vs.1.23，p=0.02）。除了儿童的压力较高之外，两组之间的ADM定量测量没有重大差异。
结论：与没有PIPO的有症状儿童和健康成人相比，回顾性诊断为PIPO的儿童有明显更多的异常ADM发现。我们的数据表明需要设定标准来评估疑似PIPO儿童的ADM。
方法：通过应用2018年ESPGHAN/NASPGHANPIPO诊断标准和2018年ANMS-NASPGHAN指南，对先前接受24小时8导联ADM调查的疑似胃肠动力障碍儿童进行了重新评估。比较了回顾性诊断为PIPO的儿童的ADM结果，没有的孩子，和健康成年人的对照组。
结果：34名儿童（7.9（±5.1）岁，18名男性），12项回顾性符合2018年PIPO诊断标准。25名儿童（PIPO组10名）在ADM上有异常诊断结果，而9人(PIPO组2人)没有这样的发现。PIPO诊断暗示ADM模式异常程度明显更高（2.33vs.1.23，p=0.02）。除了儿童的压力较高之外，两组之间的ADM定量测量没有重大差异。
结论：与没有PIPO的有症状儿童和健康成人相比，回顾性诊断为PIPO的儿童有明显更多的异常ADM发现。我们的数据表明需要设定标准来评估疑似PIPO儿童的ADM。
