Abstract：
Endothelial cells (ECs) are a multifaceted component of the vascular system with roles in immunity, maintaining tissue fluid balance, and vascular tone. Dysregulation or dysfunction of ECs can have far-reaching implications, leading pathologies ranging from cardiovascular diseases, such as hypertension and atherosclerosis, ischemia, chronic kidney disease, blood-brain barrier integrity, dementia, and tumor metastasis. Recent advancements in regenerative medicine have highlighted the potential of stem cell-derived ECs, particularly from induced pluripotent stem cells, to treat ischemic tissues, as well as models of vascular integrity. This review summarizes what is known in the generation of ECs with an emphasis on tissue-specific ECs and EC subphenotypes important in the development of targeted cell-based therapies for patient treatment.
摘要：
内皮细胞（ECs）是血管系统的多方面组成部分，在免疫中起作用，维持组织液平衡,和血管张力。内皮细胞的失调或功能障碍可能会产生深远的影响，主要病理范围从心血管疾病，比如高血压和动脉粥样硬化，缺血,慢性肾病,血脑屏障完整性，痴呆症,和肿瘤转移。再生医学的最新进展突出了干细胞衍生的ECs的潜力，特别是来自诱导多能干细胞（iPSCs），治疗缺血组织，以及血管完整性模型。这篇综述将总结在ECs的产生中已知的内容，重点是组织特异性ECs和EC亚表型，这对开发针对患者治疗的靶向细胞疗法很重要。
