Abstract：
It is imperative to optimise health and healthspan across the lifespan. The accumulation of reactive oxygen species (ROS) has been implicated in the hallmarks of ageing and inhibiting ROS production can potentially delay ageing whilst increasing healthy longevity. Lipids and lipid mediators (derivatives of lipids) are becoming increasingly recognized as central molecule in tissue and cellular function and are susceptible to peroxidation; hence linked with ageing. Lipid classes implicated in the ageing process include sterols, glycerophospholipids, sphingolipids and the oxidation products of polyunsaturated fatty acids but these are not yet translated into the clinic. Further mechanistic studies are required for the understanding of lipid classes in the ageing process. Lipidomics, the system level characterisation of lipid species with respect to metabolism and function, might provide a significant and useful biological age profiling tool through longitudinal studies. Lipid profiles in different ages among healthy individuals could be harnessed as lipid biomarkers of healthy ageing with potential integration for the development of lipid-based ageing clock (lipid clock). The potential of a lipid clock includes the prediction of future morbidity or mortality, which will promote precision and healthy longevity medicine.
摘要：
必须在整个生命周期中优化健康和健康。活性氧（ROS）的积累与衰老的标志有关，抑制ROS的产生可能会延缓衰老，同时增加健康寿命。脂质和脂质介质（脂质的衍生物）越来越被认为是组织和细胞功能中的中心分子，并且易于过氧化；因此与衰老有关。与衰老过程有关的脂质类别包括固醇，甘油磷脂，鞘脂和多不饱和脂肪酸的氧化产物，但这些尚未转化为临床。需要进一步的机理研究来理解衰老过程中的脂质类别。脂质组学，脂质物种在代谢和功能方面的系统水平表征，通过纵向研究，可能会提供一个重要而有用的生物年龄剖面工具。健康个体中不同年龄的脂谱可以用作健康衰老的脂质生物标志物，并可能整合以开发基于脂质的衰老时钟（脂质时钟）。脂质时钟的潜力包括预测未来的发病率或死亡率，这将促进精准健康的长寿医学。
