Abstract：
BACKGROUND: Affective temperaments are documented predictors of psychopathology, but cumulating data suggest their relationship with coronary artery disease (CAD). We aimed to evaluate their role in relation to surrogate semiquantitative markers of coronary plaque burden, as assessed by coronary CT angiography (CCTA).
METHODS: We included 351 patients who were referred for CCTA due to suspected CAD. All patients completed the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A). The severity and extent of CAD was evaluated by CCTA, applying semiquantitative plaque burden scores, notably Segment Involvement Score (SIS) and Segment Stenosis Score (SSS). Logistic regression analyses were performed to define the predictors of CAD severity and extent.
RESULTS: Regarding the scores evaluated by TEMPS-A that consists of 110 questions, in men, significant inverse association was found between hyperthymic temperament score and SSS (β = -0.143, (95%CI: -0.091 to -0.004), p = 0.034). Compared to the TEMPS-A form, applying the abbreviated version - containing 40 questions - significant relationship between affective temperaments and SSS or SIS was found in case of both sexes. Concerning men, hyperthymic temperament was demonstrated to be independent predictor of both SSS (β = -0.193, (95%CI: -0.224 to -0.048), p = 0.004) and SIS (β = -0.194, (95%CI: -0.202 to -0.038), p = 0.004). Additionally, we proved, that significant positive association between irritable temperament and SSS (β = 0.152, (95%CI: 0.002 to 0.269), p = 0.047) and SIS (β = 0.155, (95%CI: 0.004 to 0.221), p = 0.042) exists among women.
CONCLUSIONS: Cross-sectional analysis of a single center study with self-reported questionnaires.
CONCLUSIONS: Assessment of affective temperaments could offer added value in stratifying cardiovascular risk for patients beyond traditional risk factors.
METHODS: We included 351 patients who were referred for CCTA due to suspected CAD. All patients completed the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A). The severity and extent of CAD was evaluated by CCTA, applying semiquantitative plaque burden scores, notably Segment Involvement Score (SIS) and Segment Stenosis Score (SSS). Logistic regression analyses were performed to define the predictors of CAD severity and extent.
RESULTS: Regarding the scores evaluated by TEMPS-A that consists of 110 questions, in men, significant inverse association was found between hyperthymic temperament score and SSS (β = -0.143, (95%CI: -0.091 to -0.004), p = 0.034). Compared to the TEMPS-A form, applying the abbreviated version - containing 40 questions - significant relationship between affective temperaments and SSS or SIS was found in case of both sexes. Concerning men, hyperthymic temperament was demonstrated to be independent predictor of both SSS (β = -0.193, (95%CI: -0.224 to -0.048), p = 0.004) and SIS (β = -0.194, (95%CI: -0.202 to -0.038), p = 0.004). Additionally, we proved, that significant positive association between irritable temperament and SSS (β = 0.152, (95%CI: 0.002 to 0.269), p = 0.047) and SIS (β = 0.155, (95%CI: 0.004 to 0.221), p = 0.042) exists among women.
CONCLUSIONS: Cross-sectional analysis of a single center study with self-reported questionnaires.
CONCLUSIONS: Assessment of affective temperaments could offer added value in stratifying cardiovascular risk for patients beyond traditional risk factors.
摘要：
背景：情感气质是精神病理学的预测因子，但累积数据表明它们与冠状动脉疾病（CAD）有关。我们旨在评估它们在冠状动脉斑块负荷的替代半定量标志物中的作用，通过冠状动脉CT血管造影（CCTA）评估。
方法：我们纳入了351例因疑似CAD而转诊CCTA的患者。所有患者都完成了孟菲斯的气质评估，比萨,巴黎和圣地亚哥自动问卷（TEMPS-A）。CCTA评估CAD的严重程度和程度，应用半定量斑块负荷评分，值得注意的是节段参与评分(SIS)和节段狭窄评分(SSS)。进行Logistic回归分析以确定CAD严重程度和程度的预测因子。
结果：关于TEMPS-A评估的分数，包括110个问题，在男人中,发现胸腺亢进气质评分与SSS之间存在显着负相关（β=-0.143，（95CI：-0.091至-0.004），p=0.034)。与TEMPS-A形式相比，应用缩写版本-包含40个问题-在两性的情况下，情感气质与SSS或SIS之间存在显着关系。关于男人,高超气质被证明是两种SSS的独立预测因子(β=-0.193，(95CI:-0.224至-0.048)，p=0.004）和SIS（β=-0.194，（95CI：-0.202至-0.038），p=0.004)。此外,我们证明了,易怒气质与SSS之间存在显着正相关（β=0.152，（95CI：0.002至0.269），p=0.047）和SIS（β=0.155，（95CI：0.004至0.221），p=0.042）存在于妇女中。
结论：使用自我报告问卷的单中心研究的横断面分析。
结论：情感性情评估可以为患者的心血管风险分层提供超越传统危险因素的附加价值。
方法：我们纳入了351例因疑似CAD而转诊CCTA的患者。所有患者都完成了孟菲斯的气质评估，比萨,巴黎和圣地亚哥自动问卷（TEMPS-A）。CCTA评估CAD的严重程度和程度，应用半定量斑块负荷评分，值得注意的是节段参与评分(SIS)和节段狭窄评分(SSS)。进行Logistic回归分析以确定CAD严重程度和程度的预测因子。
结果：关于TEMPS-A评估的分数，包括110个问题，在男人中,发现胸腺亢进气质评分与SSS之间存在显着负相关（β=-0.143，（95CI：-0.091至-0.004），p=0.034)。与TEMPS-A形式相比，应用缩写版本-包含40个问题-在两性的情况下，情感气质与SSS或SIS之间存在显着关系。关于男人,高超气质被证明是两种SSS的独立预测因子(β=-0.193，(95CI:-0.224至-0.048)，p=0.004）和SIS（β=-0.194，（95CI：-0.202至-0.038），p=0.004)。此外,我们证明了,易怒气质与SSS之间存在显着正相关（β=0.152，（95CI：0.002至0.269），p=0.047）和SIS（β=0.155，（95CI：0.004至0.221），p=0.042）存在于妇女中。
结论：使用自我报告问卷的单中心研究的横断面分析。
结论：情感性情评估可以为患者的心血管风险分层提供超越传统危险因素的附加价值。
