Abstract：
Abnormal immune and inflammatory responses are considered to contribute to schizophrenia (SZ). The neutrophil/lymphocyte ratio (NLR) is an inexpensive and reproducible marker of systemic inflammatory responses. Accumulating studies have demonstrated that NLR values are increased in SZ compared to healthy controls and closely related to clinical symptoms in antipsychotic-naïve first-episode SZ (ANFES) patients. However, to our knowledge, only one study has examined NLR in relation to neurocognition in 27 first-episode psychosis patients and 27 controls. This study aimed to examine the relationship of NLR values with cognitive performances in ANFES patients with a larger sample size. Whole blood cell counts were measured in ninety-seven ANFES patients and fifty-six control subjects. The neurocognitive functions of all subjects were measured by the repeatable battery for the assessment of neuropsychological status (RBANS). ANFES patients performed worse on cognition and had increased NLR values relative to healthy controls. In addition, increased NLR was negatively associated with cognitive functions in ANFES patients. Lymphocyte count was positively correlated with cognitive functions in patients. These findings suggest that the abnormal immune and inflammation system indicated by NLR may be involved in the cognitive functions in ANFES patients.
摘要：
异常免疫和炎症反应被认为是导致精神分裂症(SZ)的原因。中性粒细胞/淋巴细胞比率(NLR)是全身性炎症反应的廉价且可重复的标志物。越来越多的研究表明，与健康对照相比，SZ的NLR值增加，并且与抗精神病药首次发作SZ（ANFES）患者的临床症状密切相关。然而,根据我们的知识，只有一项研究在27例首发精神病患者和27例对照中检测了NLR与神经认知的关系.本研究旨在研究样本量较大的ANFES患者NLR值与认知表现的关系。在97名ANFES患者和56名对照受试者中测量全血细胞计数。通过可重复电池测量所有受试者的神经认知功能，以评估神经心理学状态（RBANS）。ANFES患者的认知表现较差，相对于健康对照，NLR值增加。此外,ANFES患者NLR升高与认知功能呈负相关.淋巴细胞计数与患者认知功能呈正相关。这些发现表明，NLR指示的异常免疫和炎症系统可能与ANFES患者的认知功能有关。
