Abstract:
An 11-month-old female Saanen goat, weighing 12.7 kg, was taken to the Veterinary Hospital of the Federal University of Minas Gerais because of sternal recumbency. On clinical examination, the animal was much smaller than expected and had hair similar to that of puppies and areas of hyperpigmentation on the head and dorsocervical and dorsothoracic cranial regions. Radiographic examination revealed fractures in both femurs and severe generalized osteoporosis. Given the unfavourable prognosis, the animal was euthanized. Necropsy revealed generalized pallor, muscular atrophy of the pelvic limbs and little reserve of subcutaneous adipose tissue. Both femurs had complete and closed diaphyseal fractures. The second lumbar vertebra was severely reduced in length as a result of a fracture, with dorsal displacement of the vertebral body towards the vertebral canal and compression of the spinal cord. Long bones and vertebrae had severe cortical thinning, enlargement of the medullary canal and reduced resistance. The thyroid gland was not in its normal anatomical location. A pale red nodule (1.0 × 0.4 cm) in the serosa of the middle third of the trachea, close to the thoracic entrance, was confirmed as ectopic thyroid tissue. Microscopically, the bones had evidence of growth arrest and severe osteoporosis. The ectopic thyroid nodule was hyperplastic with severe hypertrophy of follicular cells. The spinal cord was compressed by vertebral fractures and had focally extensive and severe myelomalacia. Based on the pathological features, the case was diagnosed as thyroid dysgenesis characterized by eutopic thyroid agenesis and ectopic thyroid tissue, associated with interruption of bone growth with dwarfism, osteoporosis and spontaneous secondary fractures with compression of the lumbar spinal cord.
摘要:
一只11个月大的雌性Saanen山羊,重12.7公斤,由于胸骨卧位,被送往米纳斯吉拉斯州联邦大学兽医医院。在临床检查中,该动物比预期的要小得多,并且具有与幼犬相似的毛发,并且在头部,颈背和胸背的颅骨区域具有色素沉着过度。影像学检查显示股骨骨折和严重的全身性骨质疏松症。鉴于预后不利,动物被安乐死。尸检显示全身苍白,骨盆四肢肌肉萎缩,皮下脂肪组织储备很少。两个股骨都有完整和闭合的骨干骨折。由于骨折,第二个腰椎的长度严重缩短,椎体向椎管的背侧移位和脊髓受压。长骨和椎骨有严重的皮质变薄,髓管扩大,阻力降低。甲状腺不在其正常解剖位置。气管中三分之一浆膜浅红色结节(1.0×0.4cm),靠近胸部入口,证实为异位甲状腺组织。微观上,骨骼有生长停滞和严重骨质疏松症的证据。异位甲状腺结节增生,滤泡细胞严重肥大。脊髓因椎骨骨折而受压,并有局部广泛和严重的骨髓软化症。根据病理特征,该病例被诊断为以异位甲状腺发育不全和异位甲状腺组织为特征的甲状腺发育不全,与侏儒症的骨骼生长中断有关,骨质疏松症和自发性继发性骨折伴腰椎脊髓受压。