Abstract：
OBJECTIVE: The aim of this study was to explore the relationship between the EAT-Lancet diet (ELD) and head and neck cancers (HNCs) in 101,755 Americans enrolled in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.
METHODS: Prospective cohort study.
METHODS: ELD score was calculated to assess participant\'s adherence to ELD. Cox hazard regression models were utilised to evaluate the association of ELD and dietary components with HNC risk. Restricted cubic spline (RCS) plots were employed to explore the linearity of the relationships. Predefined subgroup analyses and sensitivity analyses were performed to identify potential effect modifiers and to assess the stability of the findings, respectively.
RESULTS: After a mean follow-up of 8.84 years, 279 cases of HNCs, including 169 cases of oral cavity and pharyngeal cancers and 110 cases of laryngeal cancer were recorded. This study observed a dose-response negative correlation between ELD and HNCs (hazard ratio [HR]Q4 vs Q1: 0.52; 95% confidence interval [CI]: 0.34, 0.80; P-trend = 0.003; HRper SD increment: 0.80; 95% CI: 0.71, 0.91), and oral cavity and pharyngeal cancers (HRQ4 vs Q1: 0.52; 95% CI: 0.31, 0.88; P-trend = 0.008; HRper SD increment: 0.78; 95% CI: 0.66, 0.92). Analysis using RCS plots indicated a significant linear association between adherence to the ELD and reduced risk of HNCs and oral cavity and pharyngeal cancers (P-nonlinearity > 0.05). Subgroup analysis did not reveal significant interaction factors (P-interaction > 0.05), and sensitivity analysis confirmed the robustness of this study. Additionally, negative correlations were found between the consumption of fruits and whole grains and HNCs (fruits: HRQ4 vs Q1: 0.58; 95% CI: 0.40, 0.84; P-trend = 0.010; whole grains: HRQ4 vs Q1: 0.51; 95% CI: 0.26, 0.97; P-trend = 0.004).
CONCLUSIONS: Adherence to ELD contributes to the prevention of HNCs.
METHODS: Prospective cohort study.
METHODS: ELD score was calculated to assess participant\'s adherence to ELD. Cox hazard regression models were utilised to evaluate the association of ELD and dietary components with HNC risk. Restricted cubic spline (RCS) plots were employed to explore the linearity of the relationships. Predefined subgroup analyses and sensitivity analyses were performed to identify potential effect modifiers and to assess the stability of the findings, respectively.
RESULTS: After a mean follow-up of 8.84 years, 279 cases of HNCs, including 169 cases of oral cavity and pharyngeal cancers and 110 cases of laryngeal cancer were recorded. This study observed a dose-response negative correlation between ELD and HNCs (hazard ratio [HR]Q4 vs Q1: 0.52; 95% confidence interval [CI]: 0.34, 0.80; P-trend = 0.003; HRper SD increment: 0.80; 95% CI: 0.71, 0.91), and oral cavity and pharyngeal cancers (HRQ4 vs Q1: 0.52; 95% CI: 0.31, 0.88; P-trend = 0.008; HRper SD increment: 0.78; 95% CI: 0.66, 0.92). Analysis using RCS plots indicated a significant linear association between adherence to the ELD and reduced risk of HNCs and oral cavity and pharyngeal cancers (P-nonlinearity > 0.05). Subgroup analysis did not reveal significant interaction factors (P-interaction > 0.05), and sensitivity analysis confirmed the robustness of this study. Additionally, negative correlations were found between the consumption of fruits and whole grains and HNCs (fruits: HRQ4 vs Q1: 0.58; 95% CI: 0.40, 0.84; P-trend = 0.010; whole grains: HRQ4 vs Q1: 0.51; 95% CI: 0.26, 0.97; P-trend = 0.004).
CONCLUSIONS: Adherence to ELD contributes to the prevention of HNCs.
摘要：
目的：这项研究的目的是探索在101,755名前列腺癌美国人中，EAT-Lancet饮食（ELD）与头颈癌（HNC）之间的关系。肺，结直肠癌和卵巢癌（PLCO）筛查试验。
方法：前瞻性队列研究。
方法：计算ELD评分以评估参与者对ELD的依从性。Cox风险回归模型用于评估ELD和饮食成分与HNC风险的关联。使用限制三次样条（RCS）图来探索关系的线性。进行了预定义的亚组分析和敏感性分析，以确定潜在的效应调节剂并评估结果的稳定性。分别。
结果：经过平均8.84年的随访，279例HNC，其中口腔癌、咽癌169例,喉癌110例。本研究观察到ELD和HNC之间的剂量反应负相关（风险比[HR]Q4与Q1：0.52；95％置信区间[CI]：0.34，0.80；P趋势=0.003；HR每SD增量：0.80；95％CI：0.71，0.91），以及口腔和咽喉癌（HRQ4vsQ1：0.52；95％CI：0.31，0.88；P趋势=0.008；HR/SD增量：0.78；95％CI：0.66，0.92）。使用RCS图的分析表明坚持ELD与降低HNC和口腔癌和咽喉癌的风险之间存在显著的线性关联(P-非线性>0.05)。亚组分析没有发现显著的交互作用因素(P交互作用>0.05),敏感性分析证实了本研究的稳健性。此外,水果和全谷物的消费量与HNC之间存在负相关（水果：HRQ4vsQ1：0.58；95％CI：0.40，0.84；P趋势=0.010；全谷物：HRQ4vsQ1：0.51；95％CI：0.26，0.97；P趋势=0.004）。
结论：坚持ELD有助于预防HNC。
方法：前瞻性队列研究。
方法：计算ELD评分以评估参与者对ELD的依从性。Cox风险回归模型用于评估ELD和饮食成分与HNC风险的关联。使用限制三次样条（RCS）图来探索关系的线性。进行了预定义的亚组分析和敏感性分析，以确定潜在的效应调节剂并评估结果的稳定性。分别。
结果：经过平均8.84年的随访，279例HNC，其中口腔癌、咽癌169例,喉癌110例。本研究观察到ELD和HNC之间的剂量反应负相关（风险比[HR]Q4与Q1：0.52；95％置信区间[CI]：0.34，0.80；P趋势=0.003；HR每SD增量：0.80；95％CI：0.71，0.91），以及口腔和咽喉癌（HRQ4vsQ1：0.52；95％CI：0.31，0.88；P趋势=0.008；HR/SD增量：0.78；95％CI：0.66，0.92）。使用RCS图的分析表明坚持ELD与降低HNC和口腔癌和咽喉癌的风险之间存在显著的线性关联(P-非线性>0.05)。亚组分析没有发现显著的交互作用因素(P交互作用>0.05),敏感性分析证实了本研究的稳健性。此外,水果和全谷物的消费量与HNC之间存在负相关（水果：HRQ4vsQ1：0.58；95％CI：0.40，0.84；P趋势=0.010；全谷物：HRQ4vsQ1：0.51；95％CI：0.26，0.97；P趋势=0.004）。
结论：坚持ELD有助于预防HNC。
