Abstract：
Light-propelled nanomotors, which can convert external light into mechanical motion, have shown considerable potential in the construction of a new generation of drug delivery systems. However, the therapeutic efficacy of light-driven nanomotors is always unsatisfactory due to the limited penetration depth of near-infrared-I (NIR-I) light and the inherent biocompatibility of the motor itself. Herein, an asymmetric nanomotor (Pd@ZIF-8/R848@M JNMs) with efficient motion capability is successfully constructed for enhanced photoimmunotherapy toward hepatocellular carcinoma. Under near-infrared-II (NIR-II) irradiation, Pd@ZIF-8/R848@M JNMs convert light energy into heat energy, exhibiting self-thermophoretic locomotion to penetrate deeper into tumor tissues to achieve photothermal therapy. At the same time, functionalized with an immune-activated agent Resiquimod (R848), our nanomotors could convert a \"cold tumor\" into a \"hot tumor\", transforming the immunosuppressive microenvironment into an immune-activated state, thus achieving immunotherapy. Dual photoimmunotherapy of the as-developed NIR-II light-driven Pd@ZIF-8/R848@M JNMs demonstrates considerable tumor inhibition effects, offering a promising therapeutic approach in the field of anticancer therapy.
摘要：
光推进纳米马达，可以将外部光线转换成机械运动，在构建新一代药物递送系统方面显示出相当大的潜力。然而,由于近红外-I(NIR-I)光的穿透深度有限和电机本身固有的生物相容性,光驱动纳米电机的治疗效果总是不能令人满意的。在这里，具有有效运动能力的不对称纳米马达(Pd@ZIF-8/R848@MJNMs)被成功构建用于增强对肝细胞癌的光免疫疗法。在近红外-II（NIR-II）照射下，Pd@ZIF-8/R848@MJNM将光能转化为热能，表现出自我热泳运动，深入肿瘤组织以实现光热治疗。同时,用免疫活化剂Resiquimod（R848）功能化，我们的纳米马达可以将“冷肿瘤”转化为“热肿瘤”将免疫抑制微环境转化为免疫激活状态，从而实现免疫治疗。已开发的NIR-II光驱动Pd@ZIF-8/R848@MJNM的双重光免疫疗法显示出相当大的肿瘤抑制作用，在抗癌治疗领域提供了一种有前途的治疗方法。
