PDF(Pubmed)
Abstract：
BACKGROUND: This study aimed to analyze corneal sensitivity with a new noncontact and handheld esthesiometer (Brill Engines, Spain) in patients with dry eye disease (DED) and patients on hypotensive drops, and to compare it with healthy subjects.
METHODS: A total of 31 patients (57 eyes) with DED, 23 patients (46 eyes) with glaucoma, and 21 healthy patients (33 eyes) were recruited. In all patients, corneal sensitivity was measured. Subsequently, a keratography test (Keratograph 5M, Oculus) was carried out to measure tear meniscus height (TMH), non-invasive breakup time (NIBUT), bulbar redness (Jenvis scale), and corneal staining (CS, Oxford scale). Both corneal sensitivity and ocular surface parameters were compared between DED, glaucoma, and healthy subjects. Linear mixed models were constructed to utilize data from both eyes of patients. An alpha level of 0.05 was considered statistically significant.
RESULTS: The mean age was 56.1 ± 16.1 years in the DED group, 69.5 ± 11.7 years in the glaucoma group, and 37.190 ± 11.677 years in the control group. After adjustment for age and sex, corneal sensitivity was significantly reduced in DED and glaucoma vs control group (P = 0.02 and P = 0.009, respectively). NIBUT was lower in DED and glaucoma groups (P < 0.001 and P = 0.001, respectively). Redness and CS values were higher in the DED group (P = 0.04 and P = 0.001, respectively). TMH was lower in the glaucoma group (P = 0.03).
CONCLUSIONS: Corneal sensitivity measured with a novel noncontact esthesiometer was reduced in DED and glaucoma groups compared to controls. In clinical practice, this esthesiometer could be an easy-to-use device to screen for patients with subclinical neurotrophic keratopathy.
METHODS: A total of 31 patients (57 eyes) with DED, 23 patients (46 eyes) with glaucoma, and 21 healthy patients (33 eyes) were recruited. In all patients, corneal sensitivity was measured. Subsequently, a keratography test (Keratograph 5M, Oculus) was carried out to measure tear meniscus height (TMH), non-invasive breakup time (NIBUT), bulbar redness (Jenvis scale), and corneal staining (CS, Oxford scale). Both corneal sensitivity and ocular surface parameters were compared between DED, glaucoma, and healthy subjects. Linear mixed models were constructed to utilize data from both eyes of patients. An alpha level of 0.05 was considered statistically significant.
RESULTS: The mean age was 56.1 ± 16.1 years in the DED group, 69.5 ± 11.7 years in the glaucoma group, and 37.190 ± 11.677 years in the control group. After adjustment for age and sex, corneal sensitivity was significantly reduced in DED and glaucoma vs control group (P = 0.02 and P = 0.009, respectively). NIBUT was lower in DED and glaucoma groups (P < 0.001 and P = 0.001, respectively). Redness and CS values were higher in the DED group (P = 0.04 and P = 0.001, respectively). TMH was lower in the glaucoma group (P = 0.03).
CONCLUSIONS: Corneal sensitivity measured with a novel noncontact esthesiometer was reduced in DED and glaucoma groups compared to controls. In clinical practice, this esthesiometer could be an easy-to-use device to screen for patients with subclinical neurotrophic keratopathy.
摘要：
背景：这项研究旨在使用新型的非接触式和手持式美学计（BrillEngines，西班牙）干眼症（DED）患者和低血压滴剂患者，并将其与健康受试者进行比较。
方法：共31例（57眼）DED患者，23例（46眼）青光眼，纳入21例健康患者(33只眼)。在所有患者中，测量角膜敏感度。随后，角膜造影试验(角膜造影5M，Oculus）进行测量泪液弯月面高度（TMH），非侵入性破裂时间（NIBUT），球根发红(Jenvis量表)，和角膜染色（CS，牛津量表)。比较DED之间的角膜敏感性和眼表参数，青光眼,和健康的受试者。构建线性混合模型以利用来自患者双眼的数据。0.05的α水平被认为是统计学上显著的。
结果：DED组的平均年龄为56.1±16.1岁，青光眼组69.5±11.7年，对照组为37.190±11.677岁。在调整了年龄和性别后，与对照组相比，DED和青光眼的角膜敏感性显着降低（分别为P=0.02和P=0.009）。DED组和青光眼组的NIBUT较低（分别为P<0.001和P=0.001）。DED组的红色和CS值较高（分别为P=0.04和P=0.001）。青光眼组TMH较低(P=0.03)。
结论：与对照组相比，DED和青光眼组用新型非接触式麻醉仪测量的角膜敏感性降低。在临床实践中,这种美感仪可能是一种易于使用的设备，用于筛查亚临床神经营养性角膜病变患者。
方法：共31例（57眼）DED患者，23例（46眼）青光眼，纳入21例健康患者(33只眼)。在所有患者中，测量角膜敏感度。随后，角膜造影试验(角膜造影5M，Oculus）进行测量泪液弯月面高度（TMH），非侵入性破裂时间（NIBUT），球根发红(Jenvis量表)，和角膜染色（CS，牛津量表)。比较DED之间的角膜敏感性和眼表参数，青光眼,和健康的受试者。构建线性混合模型以利用来自患者双眼的数据。0.05的α水平被认为是统计学上显著的。
结果：DED组的平均年龄为56.1±16.1岁，青光眼组69.5±11.7年，对照组为37.190±11.677岁。在调整了年龄和性别后，与对照组相比，DED和青光眼的角膜敏感性显着降低（分别为P=0.02和P=0.009）。DED组和青光眼组的NIBUT较低（分别为P<0.001和P=0.001）。DED组的红色和CS值较高（分别为P=0.04和P=0.001）。青光眼组TMH较低(P=0.03)。
结论：与对照组相比，DED和青光眼组用新型非接触式麻醉仪测量的角膜敏感性降低。在临床实践中,这种美感仪可能是一种易于使用的设备，用于筛查亚临床神经营养性角膜病变患者。
