Abstract：
OBJECTIVE: One prevalent therapeutic strategy for addressing atherosclerosis is using an alternative blood supply route to the heart, referred to as bypass surgery. In these surgeries, the saphenous vein, radial artery, and internal mammary artery are commonly used to create this bypass route. Unfortunately, due to negligence regarding the compatibility of the graft with the host tissue, reoperation is often required after several years. One method that can aid in selecting a suitable vein for bypass is simulating the solid-fluid interaction, and performing such simulations requires knowledge of the mechanical properties of bypass grafts. Therefore, extracting the mechanical properties of bypass grafts is essential.
METHODS: In this study, human bypass grafts were subjected to uniaxial tensile testing, and their elastic modulus was extracted and compared. Additionally, the hyperelastic properties of these grafts were extracted using the Mooney-Rivlin model for use in numerical software.
RESULTS: The average elastic modulus in the circumferential direction for radial artery, mammary artery, and saphenous vein samples were determined to be 1.384 ± 0.268 MPa, 3.108 ± 1.652 MPa, and 7.912 ± 2.509 MPa, respectively. Based on the results of uniaxial tests, the saphenous vein exhibited the highest stiffness among the three vascular tissues.
CONCLUSIONS: The mechanical characterization results of the bypass vessels can be applied to the clinical studies of heart diseases. They may help develop an appropriate treatment approach.
METHODS: In this study, human bypass grafts were subjected to uniaxial tensile testing, and their elastic modulus was extracted and compared. Additionally, the hyperelastic properties of these grafts were extracted using the Mooney-Rivlin model for use in numerical software.
RESULTS: The average elastic modulus in the circumferential direction for radial artery, mammary artery, and saphenous vein samples were determined to be 1.384 ± 0.268 MPa, 3.108 ± 1.652 MPa, and 7.912 ± 2.509 MPa, respectively. Based on the results of uniaxial tests, the saphenous vein exhibited the highest stiffness among the three vascular tissues.
CONCLUSIONS: The mechanical characterization results of the bypass vessels can be applied to the clinical studies of heart diseases. They may help develop an appropriate treatment approach.
摘要：
目的：解决动脉粥样硬化的一种普遍治疗策略是使用替代的心脏供血途径，称为搭桥手术。在这些手术中，隐静脉,桡动脉,和乳内动脉通常用于创建此旁路路径。不幸的是,由于忽略了移植物与宿主组织的相容性，几年后通常需要再次手术。一种可以帮助选择合适的旁路静脉的方法是模拟固体-流体相互作用，并且进行这样的模拟需要了解旁路移植物的机械性能。因此,提取旁路移植物的机械性能是必不可少的。
方法：在本研究中，人体旁路移植物进行单轴拉伸试验，提取并比较了它们的弹性模量。此外,这些移植物的超弹性特性是使用Mooney-Rivlin模型提取的，用于数值软件。
结果：桡动脉在圆周方向的平均弹性模量，乳腺动脉,和隐静脉样品测定为1.384±0.268MPa，3.108±1.652MPa,和7.912±2.509MPa，分别。根据单轴试验的结果，在三种血管组织中，隐静脉的硬度最高。
结论：旁路血管的力学表征结果可应用于心脏疾病的临床研究。它们可能有助于开发适当的治疗方法。
方法：在本研究中，人体旁路移植物进行单轴拉伸试验，提取并比较了它们的弹性模量。此外,这些移植物的超弹性特性是使用Mooney-Rivlin模型提取的，用于数值软件。
结果：桡动脉在圆周方向的平均弹性模量，乳腺动脉,和隐静脉样品测定为1.384±0.268MPa，3.108±1.652MPa,和7.912±2.509MPa，分别。根据单轴试验的结果，在三种血管组织中，隐静脉的硬度最高。
结论：旁路血管的力学表征结果可应用于心脏疾病的临床研究。它们可能有助于开发适当的治疗方法。
