UNASSIGNED: This study constitutes the first comprehensive review to assess the effectiveness and underlying mechanisms of biologics for PPP.
UNASSIGNED: We conducted a PubMed search to identify studies on biologics for PPP from 1992 onward. The review focused on assessing the efficacy of biologics targeting cytokines like IL-1, IL-8, IL-17, IL-12/23, IL-36, and TNF-α.
UNASSIGNED: Biologics for PPP are generally less effective than for psoriasis. Secukinumab and guselkumab, IL-17 and IL-23 inhibitors respectively, have shown better results compared to other biologics in trials. However, the effectiveness of other biologics remains uncertain due to limited data.
UNASSIGNED: More research is needed to find effective treatments for PPP, and selecting the right biologic for each patient is challenging.
■这项研究是评估PPP生物制剂有效性和潜在机制的第一次全面审查。
■我们进行了PubMed搜索,以确定从1992年开始的PPP生物制剂研究。该综述集中于评估生物制剂靶向细胞因子如IL-1,IL-8,IL-17,IL-12/23,IL-36和TNF-α的功效。
■PPP的生物制剂通常不如牛皮癣有效。Secukinumab和guselkumab,IL-17和IL-23抑制剂与其他生物制剂相比,在试验中显示出更好的结果。然而,由于数据有限,其他生物制剂的有效性仍不确定。
■需要更多的研究来寻找PPP的有效治疗方法,为每个患者选择合适的生物制剂是具有挑战性的。