PDF(Pubmed)
Abstract：
Diabetic retinopathy is the major cause of blindness in diabetic patients, with limited treatment options that do not always restore optimal vision. Retinal nerve degeneration and vascular degeneration are two primary pathological processes of diabetic retinopathy. The retinal nervous system and vascular cells have a close coupling relationship. The connection between neurodegeneration and vascular degeneration is not yet fully understood. Recent studies have found that microRNA plays a role in regulating diabetic retinal neurovascular degeneration and can help delay the progression of the disease. This article will review how microRNA acts as a bridge connecting diabetic retinal neurodegeneration and vascular degeneration, focusing on the mechanisms of apoptosis, oxidative stress, inflammation, and endothelial factors. The aim is to identify valuable targets for new research and clinical treatment of diabetic retinopathy.
摘要：
糖尿病视网膜病变是糖尿病患者致盲的主要原因,有限的治疗选择，并不总是恢复最佳视力。视网膜神经变性和血管变性是糖尿病视网膜病变的两个主要病理过程。视网膜神经体系与血管细胞具有亲密的耦合关系。神经变性与血管变性之间的联系尚未完全理解。近年来研究发现microRNA在调节糖尿病视网膜神经血管变性中起作用,有助于延缓疾病进展。本文将回顾microRNA如何作为连接糖尿病视网膜神经变性和血管变性的桥梁，专注于细胞凋亡的机制，氧化应激，炎症,和内皮因子。目的是为糖尿病视网膜病变的新研究和临床治疗确定有价值的目标。
