PDF(Pubmed)
Abstract：
The consequences caused by bacterial resistance are becoming more and more serious. The rate of antibiotic development is far behind the rate of bacterial resistance, so it is urgent to develop a new drug system. In this study, photoresponsive nanogels based on hyaluronic acid were prepared and loaded with ciprofloxacin as a model molecule. The results showed that the nanogels had the advantages of high stability and good cytocompatibility. The inhibition effect of drug-loaded nanogels after light irradiation on the growth of Staphylococcus aureus and Salmonella typhimurium was significantly better than that before light irradiation, and ciprofloxacin could be released on demand and in control. This strategy is of great significance to reduce the unnecessary use of antibiotics and weaken bacterial resistance.
摘要：
细菌耐药所带来的后果日趋严重。抗生素的发展速度远远落后于细菌的耐药性，因此，迫切需要开发新的药物系统。在这项研究中,制备了基于透明质酸的光响应性纳米凝胶，并以环丙沙星为模型分子。结果表明,纳米凝胶具有稳定性高、细胞相容性好等优点。光照射后载药纳米凝胶对金黄色葡萄球菌和鼠伤寒沙门氏菌生长的抑制作用明显优于光照射前,环丙沙星可以根据需要和控制释放。该策略对减少抗生素的不必要使用和削弱细菌耐药性具有重要意义。
