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Abstract：
Sepsis is a syndrome that causes dysfunction of multiple organs due to the host\'s uncontrolled response to infection and is a significant contributor to morbidity and mortality in intensive care units worldwide. Surviving patients are often left with acute brain injury and long-term cognitive impairment, known as sepsis-associated encephalopathy (SAE). In recent years, researchers have directed their focus towards the pathogenesis of SAE. However, due to the complexity of its development, there remains a lack of effective treatment measures that arise as a serious issue affecting the prognosis of sepsis patients. Further research on the possible causes of SAE aims to provide clinicians with potential therapeutic targets and help develop targeted prevention strategies. This paper aims to review recent research on the pathogenesis of SAE, in order to enhance our understanding of this syndrome.
摘要：
脓毒症是一种由于宿主对感染的不受控制的反应而导致多器官功能障碍的综合征，是全球重症监护病房发病率和死亡率的重要原因。存活的患者往往有急性脑损伤和长期认知障碍，被称为脓毒症相关性脑病（SAE）。近年来,研究人员将重点放在SAE的发病机制上。然而,由于其发展的复杂性，仍然缺乏有效的治疗措施，这是影响脓毒症患者预后的严重问题。对SAE可能原因的进一步研究旨在为临床医生提供潜在的治疗目标，并帮助制定有针对性的预防策略。本文就近年来关于SAE发病机制的研究作一综述,以增强我们对这种综合征的认识。
