PDF(Pubmed)
Abstract：
UNASSIGNED: Carbapenemase-producing Enterobacterales (CPE) represents a significant threat to global health. This study aimed to characterize clinically and molecularly the CPE isolated from rectal swabs of patients in the intensive care units (ICUs) of a tertiary hospital in Cali, Colombia.
UNASSIGNED: This was a cross-sectional observational study. Rectal swabs from patients admitted to the ICUs were collected. Bacterial identification and carbapenemase production were determined using phenotypic and molecular methods. Demographic and clinical data were extracted from electronic medical records.
UNASSIGNED: The study included 223 patients. Thirty-six patients (36/223, 16.14 %) were found to be colonized or infected by CPE. Factors such as prolonged stay in the ICU, previous exposure to carbapenem antibiotics, use of invasive procedures, and admission due to trauma were associated with CPE. Klebsiella pneumoniae (52.5 %) was the most prevalent microorganism, and the dominant carbapenemases identified were KPC (57.8 %) and NDM (37.8 %).
UNASSIGNED: Distinguishing carbapenemase subtypes can provide crucial insights for controlling dissemination in ICUs in Cali, Colombia.
UNASSIGNED: This was a cross-sectional observational study. Rectal swabs from patients admitted to the ICUs were collected. Bacterial identification and carbapenemase production were determined using phenotypic and molecular methods. Demographic and clinical data were extracted from electronic medical records.
UNASSIGNED: The study included 223 patients. Thirty-six patients (36/223, 16.14 %) were found to be colonized or infected by CPE. Factors such as prolonged stay in the ICU, previous exposure to carbapenem antibiotics, use of invasive procedures, and admission due to trauma were associated with CPE. Klebsiella pneumoniae (52.5 %) was the most prevalent microorganism, and the dominant carbapenemases identified were KPC (57.8 %) and NDM (37.8 %).
UNASSIGNED: Distinguishing carbapenemase subtypes can provide crucial insights for controlling dissemination in ICUs in Cali, Colombia.
摘要：
产生碳青霉烯酶的肠杆菌(CPE)对全球健康构成重大威胁。这项研究旨在在临床和分子上表征从卡利三级医院重症监护病房（ICU）患者的直肠拭子中分离出的CPE，哥伦比亚。
■这是一项横断面观察性研究。收集来自ICU的患者的直肠拭子。使用表型和分子方法确定细菌鉴定和碳青霉烯酶的产生。从电子病历中提取人口统计学和临床数据。
■该研究包括223名患者。36例(36/223,16.14%)被CPE定植或感染。因素，如长期留在ICU，以前接触过碳青霉烯类抗生素，使用侵入性程序，创伤所致入院与CPE相关。肺炎克雷伯菌(52.5%)是最常见的微生物,主要碳青霉烯酶为KPC(57.8%)和NDM(37.8%)。
■区分碳青霉烯酶亚型可以为控制卡利ICU的传播提供关键见解，哥伦比亚。
■这是一项横断面观察性研究。收集来自ICU的患者的直肠拭子。使用表型和分子方法确定细菌鉴定和碳青霉烯酶的产生。从电子病历中提取人口统计学和临床数据。
■该研究包括223名患者。36例(36/223,16.14%)被CPE定植或感染。因素，如长期留在ICU，以前接触过碳青霉烯类抗生素，使用侵入性程序，创伤所致入院与CPE相关。肺炎克雷伯菌(52.5%)是最常见的微生物,主要碳青霉烯酶为KPC(57.8%)和NDM(37.8%)。
■区分碳青霉烯酶亚型可以为控制卡利ICU的传播提供关键见解，哥伦比亚。
