PDF(Pubmed)
Abstract：
The drugs extending healthspan in clinic have always been searched. Nitazoxanide is an FDA-approved clinical antiprotozoal drug. Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo. Our previous studies find that nitazoxanide and its metabolite tizoxanide induce mild mitochondrial uncoupling and activate cellular AMPK, oral nitazoxanide protects against experimental hyperlipidemia, hepatic steatosis, and atherosclerosis. Here, we demonstrate that both nitazoxanide and tizoxanide extend the lifespan and healthspan of Caenorhabditis elegans through Akt/AMPK/sir 2.1/daf16 pathway. Additionally, both nitazoxanide and tizoxanide improve high glucose-induced shortening of C. elegans lifespan. Nitazoxanide has been a clinical drug with a good safety profile, we suggest that it is a novel anti-aging drug.
摘要：
一直在搜索在临床上延长健康寿命的药物。硝唑尼特是FDA批准的临床抗原虫药物。硝唑尼特在体内吸收后迅速代谢为替唑尼特。我们以前的研究发现，硝唑尼特及其代谢产物替唑尼特诱导轻度线粒体解偶联并激活细胞AMPK，口服硝唑尼特可预防实验性高脂血症，肝脂肪变性,和动脉粥样硬化。这里,我们证明,硝唑尼特和替唑尼特均可通过Akt/AMPK/sir2.1/daf16途径延长秀丽隐杆线虫的寿命和健康时间.此外,硝唑尼特和替唑尼特均可改善高糖诱导的C.elegans寿命缩短。硝唑尼特是一种具有良好安全性的临床药物，我们认为它是一种新型的抗衰老药物。
