PDF(Pubmed)
Abstract：
UNASSIGNED: Concurrent chemoradiotherapy is the preferred treatment for stage IVB cervical cancer; however, some patients experience a poor prognosis. The prognostic significance of body composition indicators, including visceral obesity, has been extensively investigated in patients with cancer. This study aimed to assess the impact of body composition indicators, specifically pretreatment fat content, on the survival outcomes of patients with stage IVB cervical cancer.
UNASSIGNED: We retrospectively analyzed clinical information from patients diagnosed with stage IVB cervical cancer between 2010 and 2018. We measured visceral obesity (visceral-to-subcutaneous adipose tissue area ratio [VSR]) and skeletal muscle index (SMI) on pretreatment computed tomography (CT) images. We evaluated the impact of these body composition parameters on the prognosis of patients with cervical cancer.
UNASSIGNED: Overall, 116 patients were included, 81 of whom had complete clinical and imaging information. Based on the cut-off values from X-tile analysis, we categorized patients into high and low VSR and SMI groups. The overall survival (OS) rate of patients with a high VSR was significantly higher than that of patients with a low VSR (P = 0.022). Multivariate Cox regression analysis showed that a low VSR was an independent risk factor for the prognosis of patients with stage IVB cervical cancer.
UNASSIGNED: Visceral obesity before radiotherapy and chemotherapy has a protective effect on the prognosis of patients with stage IVB cervical cancer, while low muscle index and VSR are associated with poor prognosis.
UNASSIGNED: We retrospectively analyzed clinical information from patients diagnosed with stage IVB cervical cancer between 2010 and 2018. We measured visceral obesity (visceral-to-subcutaneous adipose tissue area ratio [VSR]) and skeletal muscle index (SMI) on pretreatment computed tomography (CT) images. We evaluated the impact of these body composition parameters on the prognosis of patients with cervical cancer.
UNASSIGNED: Overall, 116 patients were included, 81 of whom had complete clinical and imaging information. Based on the cut-off values from X-tile analysis, we categorized patients into high and low VSR and SMI groups. The overall survival (OS) rate of patients with a high VSR was significantly higher than that of patients with a low VSR (P = 0.022). Multivariate Cox regression analysis showed that a low VSR was an independent risk factor for the prognosis of patients with stage IVB cervical cancer.
UNASSIGNED: Visceral obesity before radiotherapy and chemotherapy has a protective effect on the prognosis of patients with stage IVB cervical cancer, while low muscle index and VSR are associated with poor prognosis.
摘要：
■同步放化疗是IVB期宫颈癌的首选治疗方法；然而，一些患者预后不良。身体成分指标的预后意义，包括内脏肥胖，已经在癌症患者中进行了广泛的研究。这项研究旨在评估身体成分指标的影响，特别是预处理脂肪含量，IVB期宫颈癌患者的生存结局。
■我们回顾性分析了2010年至2018年诊断为IVB期宫颈癌的患者的临床信息。我们在预处理计算机断层扫描（CT）图像上测量了内脏肥胖（内脏与皮下脂肪组织面积比[VSR]）和骨骼肌指数（SMI）。我们评估了这些身体成分参数对宫颈癌患者预后的影响。
■总的来说，包括116名患者，其中81人具有完整的临床和影像学信息。根据X-tile分析的截止值，我们将患者分为高VSR和低VSR和SMI组.高VSR患者的总生存率(OS)明显高于低VSR患者(P=0.022)。多因素Cox回归分析显示低VSR是影响IVB期宫颈癌患者预后的独立危险因素。
■放化疗前内脏肥胖对IVB期宫颈癌患者预后有保护作用，而低肌肉指数和VSR与不良预后相关。
■我们回顾性分析了2010年至2018年诊断为IVB期宫颈癌的患者的临床信息。我们在预处理计算机断层扫描（CT）图像上测量了内脏肥胖（内脏与皮下脂肪组织面积比[VSR]）和骨骼肌指数（SMI）。我们评估了这些身体成分参数对宫颈癌患者预后的影响。
■总的来说，包括116名患者，其中81人具有完整的临床和影像学信息。根据X-tile分析的截止值，我们将患者分为高VSR和低VSR和SMI组.高VSR患者的总生存率(OS)明显高于低VSR患者(P=0.022)。多因素Cox回归分析显示低VSR是影响IVB期宫颈癌患者预后的独立危险因素。
■放化疗前内脏肥胖对IVB期宫颈癌患者预后有保护作用，而低肌肉指数和VSR与不良预后相关。
