UNASSIGNED: We retrospectively analyzed clinical information from patients diagnosed with stage IVB cervical cancer between 2010 and 2018. We measured visceral obesity (visceral-to-subcutaneous adipose tissue area ratio [VSR]) and skeletal muscle index (SMI) on pretreatment computed tomography (CT) images. We evaluated the impact of these body composition parameters on the prognosis of patients with cervical cancer.
UNASSIGNED: Overall, 116 patients were included, 81 of whom had complete clinical and imaging information. Based on the cut-off values from X-tile analysis, we categorized patients into high and low VSR and SMI groups. The overall survival (OS) rate of patients with a high VSR was significantly higher than that of patients with a low VSR (P = 0.022). Multivariate Cox regression analysis showed that a low VSR was an independent risk factor for the prognosis of patients with stage IVB cervical cancer.
UNASSIGNED: Visceral obesity before radiotherapy and chemotherapy has a protective effect on the prognosis of patients with stage IVB cervical cancer, while low muscle index and VSR are associated with poor prognosis.
■我们回顾性分析了2010年至2018年诊断为IVB期宫颈癌的患者的临床信息。我们在预处理计算机断层扫描(CT)图像上测量了内脏肥胖(内脏与皮下脂肪组织面积比[VSR])和骨骼肌指数(SMI)。我们评估了这些身体成分参数对宫颈癌患者预后的影响。
■总的来说,包括116名患者,其中81人具有完整的临床和影像学信息。根据X-tile分析的截止值,我们将患者分为高VSR和低VSR和SMI组.高VSR患者的总生存率(OS)明显高于低VSR患者(P=0.022)。多因素Cox回归分析显示低VSR是影响IVB期宫颈癌患者预后的独立危险因素。
■放化疗前内脏肥胖对IVB期宫颈癌患者预后有保护作用,而低肌肉指数和VSR与不良预后相关。