PDF(Pubmed)
Abstract：
UNASSIGNED: Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance, and is also a major preventable cause of cancer. Unlike other psychoactive substances, such as nicotine, the mechanisms underlying addiction to areca nuts and related oncogenesis remain elusive. Recent reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human body. Thus, this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on humans.
UNASSIGNED: A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings (MeSH). Protein-protein interaction (PPI) networks and functional enrichment were analyzed. The results obtained for both psychoactive substances were compared.
UNASSIGNED: Given the limited number of common proteins (36/226, 16%) in the two sets, a substantial overlap (612/1176 nodes, 52%) was observed in the PPI networks, as well as in Gene Ontology. Areca nuts mainly affect signaling pathways through three hub proteins (alpha serine/threonine-protein kinase, tumor protein 53, and interleukin-6), which are common to both psychoactive substances, as well as two unique hub proteins (epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism). Areca nut-related proteins are associated with unique pathways, such as extracellular matrix organization, lipid storage, and metabolism, which are not found in nicotine-associated proteins.
UNASSIGNED: Areca nuts affect regulatory mechanisms, leading to systemic toxicity and oncogenesis. Areca nuts also affect unique pathways that can be studied as potential markers of exposure, as well as targets for anticancer therapeutic agents.
UNASSIGNED: A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings (MeSH). Protein-protein interaction (PPI) networks and functional enrichment were analyzed. The results obtained for both psychoactive substances were compared.
UNASSIGNED: Given the limited number of common proteins (36/226, 16%) in the two sets, a substantial overlap (612/1176 nodes, 52%) was observed in the PPI networks, as well as in Gene Ontology. Areca nuts mainly affect signaling pathways through three hub proteins (alpha serine/threonine-protein kinase, tumor protein 53, and interleukin-6), which are common to both psychoactive substances, as well as two unique hub proteins (epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism). Areca nut-related proteins are associated with unique pathways, such as extracellular matrix organization, lipid storage, and metabolism, which are not found in nicotine-associated proteins.
UNASSIGNED: Areca nuts affect regulatory mechanisms, leading to systemic toxicity and oncogenesis. Areca nuts also affect unique pathways that can be studied as potential markers of exposure, as well as targets for anticancer therapeutic agents.
摘要：
■槟榔/槟榔/槟榔是最常用的精神活性物质之一，也是癌症的主要可预防原因。与其他精神活性物质不同，比如尼古丁,槟榔成瘾和相关肿瘤发生的潜在机制仍然难以捉摸。最近的报告表明，尼古丁和槟榔在人体中的作用机制可能存在重叠。因此，本研究旨在探讨与槟榔接触相关的人类蛋白质的相互作用，以及这两种精神活性物质对人类影响的复杂异同。
■使用医学主题标题（MeSH）的术语从可用文献中获得与槟榔使用相关的蛋白质列表。分析了蛋白质-蛋白质相互作用（PPI）网络和功能富集。比较了两种精神活性物质的结果。
■鉴于两组中常见蛋白质的数量有限（36/226，16％），大量重叠(612/1176个节点，52%)在PPI网络中观察到，以及基因本体论。槟榔主要通过三种hub蛋白（α丝氨酸/苏氨酸蛋白激酶，肿瘤蛋白53和白细胞介素6），这两种精神活性物质都很常见，以及两种独特的hub蛋白（表皮生长因子受体和细胞周期进入和增殖代谢的主调节因子）。槟榔相关的蛋白质与独特的途径有关，如细胞外基质组织，脂质储存，和新陈代谢，在尼古丁相关蛋白质中没有发现。
■槟榔会影响监管机制，导致全身毒性和肿瘤发生。槟榔也会影响独特的途径，这些途径可以作为潜在的暴露标志物进行研究，以及抗癌治疗剂的靶标。
■使用医学主题标题（MeSH）的术语从可用文献中获得与槟榔使用相关的蛋白质列表。分析了蛋白质-蛋白质相互作用（PPI）网络和功能富集。比较了两种精神活性物质的结果。
■鉴于两组中常见蛋白质的数量有限（36/226，16％），大量重叠(612/1176个节点，52%)在PPI网络中观察到，以及基因本体论。槟榔主要通过三种hub蛋白（α丝氨酸/苏氨酸蛋白激酶，肿瘤蛋白53和白细胞介素6），这两种精神活性物质都很常见，以及两种独特的hub蛋白（表皮生长因子受体和细胞周期进入和增殖代谢的主调节因子）。槟榔相关的蛋白质与独特的途径有关，如细胞外基质组织，脂质储存，和新陈代谢，在尼古丁相关蛋白质中没有发现。
■槟榔会影响监管机制，导致全身毒性和肿瘤发生。槟榔也会影响独特的途径，这些途径可以作为潜在的暴露标志物进行研究，以及抗癌治疗剂的靶标。
