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Abstract：
OBJECTIVE: To investigate the clinical features of the ocular surface in patients with different degrees of myopia.
METHODS: A cross-sectional study was conducted involving 122 participants with myopia in Beijing Tongren Hospital from February to June, 2023. After completing the Ocular Surface Disease Index (OSDI) score scale, measurements were taken for refraction, biometric parameters and ocular surface parameters. The prevalence, severity and related parameters of the dry eye among different groups based on axial length (AL) were compared. Correlation analysis was performed between ocular surface parameters and refraction/biometric measurement parameters.
RESULTS: Statistically significant differences were observed in refractive error, corneal thickness, anterior chamber depth, and subfoveal choroidal thickness among the groups (all P<0.05). With the increase in AL, the incidence and severity of dry eye increased significantly (P<0.05). Moreover, the tear film break-up time (BUT) shortened (P<0.05), and the corneal fluorescein staining (CFS) points increased significantly (P<0.05). OSDI scores were positively correlated with AL and spherical equivalent (SE; both P<0.05); BUT was negatively correlated with AL, SE, and corneal astigmatism (AST; all P<0.05); Schirmer I test (SIT) results were negatively correlated with AL and SE (both P<0.05).
CONCLUSIONS: AL elongation is a risk factor for dry eye onset in myopic participants. The longer the AL, the more severe the dry eye is, with the increased CFS spots and tear film instability. Additionally, SE and AST exhibit negative correlations with dry eye symptom scores and ocular surface parameters.
METHODS: A cross-sectional study was conducted involving 122 participants with myopia in Beijing Tongren Hospital from February to June, 2023. After completing the Ocular Surface Disease Index (OSDI) score scale, measurements were taken for refraction, biometric parameters and ocular surface parameters. The prevalence, severity and related parameters of the dry eye among different groups based on axial length (AL) were compared. Correlation analysis was performed between ocular surface parameters and refraction/biometric measurement parameters.
RESULTS: Statistically significant differences were observed in refractive error, corneal thickness, anterior chamber depth, and subfoveal choroidal thickness among the groups (all P<0.05). With the increase in AL, the incidence and severity of dry eye increased significantly (P<0.05). Moreover, the tear film break-up time (BUT) shortened (P<0.05), and the corneal fluorescein staining (CFS) points increased significantly (P<0.05). OSDI scores were positively correlated with AL and spherical equivalent (SE; both P<0.05); BUT was negatively correlated with AL, SE, and corneal astigmatism (AST; all P<0.05); Schirmer I test (SIT) results were negatively correlated with AL and SE (both P<0.05).
CONCLUSIONS: AL elongation is a risk factor for dry eye onset in myopic participants. The longer the AL, the more severe the dry eye is, with the increased CFS spots and tear film instability. Additionally, SE and AST exhibit negative correlations with dry eye symptom scores and ocular surface parameters.
摘要：
目的：探讨不同程度近视患者眼表的临床特点。
方法：于2月至6月在北京同仁医院进行了一项横断面研究，涉及122名近视患者，2023年。完成眼表疾病指数（OSDI）评分量表后，进行了折射测量，生物参数和眼表参数。患病率,根据眼轴长度(AL)比较不同组干眼的严重程度和相关参数。在眼表参数与屈光/生物测量参数之间进行相关性分析。
结果：观察到屈光不正的统计学差异，角膜厚度,前房深度,各组间脉络膜厚度及中央凹下脉络膜厚度差异均有统计学意义(均P<0.05)。随着AL的增加，干眼的发生率和严重程度均显著增加(P<0.05)。此外，泪膜破裂时间(BUT)缩短(P<0.05),角膜荧光素染色（CFS）点明显增加（P<0.05）。OSDI评分与AL和球面当量呈正相关(SE;均P<0.05);BUT与AL呈负相关,SE,角膜散光(AST;均P<0.05);SchirmerI检验(SIT)结果与AL、SE呈负相关(均P<0.05)。
结论：AL伸长是近视患者干眼发病的危险因素。AL越长，干眼症越严重,随着CFS斑点和泪膜不稳定性的增加。此外,SE和AST与干眼症状评分和眼表参数呈负相关。
方法：于2月至6月在北京同仁医院进行了一项横断面研究，涉及122名近视患者，2023年。完成眼表疾病指数（OSDI）评分量表后，进行了折射测量，生物参数和眼表参数。患病率,根据眼轴长度(AL)比较不同组干眼的严重程度和相关参数。在眼表参数与屈光/生物测量参数之间进行相关性分析。
结果：观察到屈光不正的统计学差异，角膜厚度,前房深度,各组间脉络膜厚度及中央凹下脉络膜厚度差异均有统计学意义(均P<0.05)。随着AL的增加，干眼的发生率和严重程度均显著增加(P<0.05)。此外，泪膜破裂时间(BUT)缩短(P<0.05),角膜荧光素染色（CFS）点明显增加（P<0.05）。OSDI评分与AL和球面当量呈正相关(SE;均P<0.05);BUT与AL呈负相关,SE,角膜散光(AST;均P<0.05);SchirmerI检验(SIT)结果与AL、SE呈负相关(均P<0.05)。
结论：AL伸长是近视患者干眼发病的危险因素。AL越长，干眼症越严重,随着CFS斑点和泪膜不稳定性的增加。此外,SE和AST与干眼症状评分和眼表参数呈负相关。
