PDF(Pubmed)
Abstract：
UNASSIGNED: Previous observational studies have reported a close association between socioeconomic status and pulmonary disease-related morbidity. However, the inherent causal effects remain unclear. Therefore, this bidirectional Mendelian randomization (MR) study aimed to identify the causal relationship between household income and genetic susceptibility to pulmonary diseases.
UNASSIGNED: An MR study was conducted on a large cohort of European individuals, using publicly available genome-wide association study datasets using a random-effects inverse-variance weighting model as the main standard. Simultaneously, MR-Egger regression, weighted median, and maximum likelihood estimation were applied as supplements. Sensitivity analysis, comprising a heterogeneity test and horizontal pleiotropy test, was performed using the Cochran\'s Q, MR-Egger intercept, and MR-PRESSO tests to ensure the reliability of the conclusion.
UNASSIGNED: A higher household income tended to lower the risk of genetic susceptibility to chronic obstructive pulmonary disease (COPD, OR: 0.497, 95% CI = 0.337-0.733, p < 0.001), asthma (OR: 0.687, 95% CI = 0.540-0.876, p = 0.002), and lung cancer (OR: 0.569, 95% CI = 0.433-0.748, p < 0.001), and further indicated potential causality with pneumonia (OR: 0.817; 95% CI = 0.686-0.972, p = 0.022). No association was evident with COVID-19 (OR: 0.934, 95% CI = 0.764-1.142, p = 0.507), tuberculosis (OR: 0.597, 95% CI = 0.512-1.189, p = 0.120), or bronchiectasis (OR: 0.680, 95% CI = 0.311-1.489, p = 0.400). Reverse MR analysis suggested no reverse causal relationship between pulmonary disease and household income status, while sensitivity analysis verified the reliability of the results.
UNASSIGNED: The results revealed that the population with a higher household income tended to have a lower risk of genetic susceptibility to COPD, asthma, and lung cancer.
UNASSIGNED: An MR study was conducted on a large cohort of European individuals, using publicly available genome-wide association study datasets using a random-effects inverse-variance weighting model as the main standard. Simultaneously, MR-Egger regression, weighted median, and maximum likelihood estimation were applied as supplements. Sensitivity analysis, comprising a heterogeneity test and horizontal pleiotropy test, was performed using the Cochran\'s Q, MR-Egger intercept, and MR-PRESSO tests to ensure the reliability of the conclusion.
UNASSIGNED: A higher household income tended to lower the risk of genetic susceptibility to chronic obstructive pulmonary disease (COPD, OR: 0.497, 95% CI = 0.337-0.733, p < 0.001), asthma (OR: 0.687, 95% CI = 0.540-0.876, p = 0.002), and lung cancer (OR: 0.569, 95% CI = 0.433-0.748, p < 0.001), and further indicated potential causality with pneumonia (OR: 0.817; 95% CI = 0.686-0.972, p = 0.022). No association was evident with COVID-19 (OR: 0.934, 95% CI = 0.764-1.142, p = 0.507), tuberculosis (OR: 0.597, 95% CI = 0.512-1.189, p = 0.120), or bronchiectasis (OR: 0.680, 95% CI = 0.311-1.489, p = 0.400). Reverse MR analysis suggested no reverse causal relationship between pulmonary disease and household income status, while sensitivity analysis verified the reliability of the results.
UNASSIGNED: The results revealed that the population with a higher household income tended to have a lower risk of genetic susceptibility to COPD, asthma, and lung cancer.
摘要：
■以前的观察性研究报道了社会经济状况与肺部疾病相关发病率之间的密切关系。然而,固有的因果效应仍不清楚.因此,这项双向孟德尔随机化(MR)研究旨在确定家庭收入与肺部疾病遗传易感性之间的因果关系.
■对大量欧洲人进行了MR研究，使用公开可用的全基因组关联研究数据集，使用随机效应逆方差加权模型作为主要标准。同时,MR-Egger回归，加权中位数，和最大似然估计作为补充。敏感性分析,包括异质性测试和水平多效性测试，是用科克伦的Q进行的，MR-Egger截获,和MR-PRESSO测试，以确保结论的可靠性。
■较高的家庭收入倾向于降低慢性阻塞性肺疾病遗传易感性的风险（COPD，OR：0.497，95%CI=0.337-0.733，p<0.001），哮喘（OR：0.687，95%CI=0.540-0.876，p=0.002），和肺癌（OR：0.569，95％CI=0.433-0.748，p<0.001），并进一步表明与肺炎的潜在因果关系（OR：0.817；95％CI=0.686-0.972，p=0.022）。与COVID-19无明显关联(OR:0.934,95%CI=0.764-1.142,p=0.507),结核病（OR：0.597，95%CI=0.512-1.189，p=0.120），或支气管扩张（OR：0.680，95%CI=0.311-1.489，p=0.400）。反向MR分析表明肺部疾病与家庭收入状况之间没有反向因果关系，敏感性分析验证了结果的可靠性。
■结果显示，家庭收入较高的人群对COPD的遗传易感性风险较低，哮喘,还有肺癌.
■对大量欧洲人进行了MR研究，使用公开可用的全基因组关联研究数据集，使用随机效应逆方差加权模型作为主要标准。同时,MR-Egger回归，加权中位数，和最大似然估计作为补充。敏感性分析,包括异质性测试和水平多效性测试，是用科克伦的Q进行的，MR-Egger截获,和MR-PRESSO测试，以确保结论的可靠性。
■较高的家庭收入倾向于降低慢性阻塞性肺疾病遗传易感性的风险（COPD，OR：0.497，95%CI=0.337-0.733，p<0.001），哮喘（OR：0.687，95%CI=0.540-0.876，p=0.002），和肺癌（OR：0.569，95％CI=0.433-0.748，p<0.001），并进一步表明与肺炎的潜在因果关系（OR：0.817；95％CI=0.686-0.972，p=0.022）。与COVID-19无明显关联(OR:0.934,95%CI=0.764-1.142,p=0.507),结核病（OR：0.597，95%CI=0.512-1.189，p=0.120），或支气管扩张（OR：0.680，95%CI=0.311-1.489，p=0.400）。反向MR分析表明肺部疾病与家庭收入状况之间没有反向因果关系，敏感性分析验证了结果的可靠性。
■结果显示，家庭收入较高的人群对COPD的遗传易感性风险较低，哮喘,还有肺癌.
