UNASSIGNED: An MR study was conducted on a large cohort of European individuals, using publicly available genome-wide association study datasets using a random-effects inverse-variance weighting model as the main standard. Simultaneously, MR-Egger regression, weighted median, and maximum likelihood estimation were applied as supplements. Sensitivity analysis, comprising a heterogeneity test and horizontal pleiotropy test, was performed using the Cochran\'s Q, MR-Egger intercept, and MR-PRESSO tests to ensure the reliability of the conclusion.
UNASSIGNED: A higher household income tended to lower the risk of genetic susceptibility to chronic obstructive pulmonary disease (COPD, OR: 0.497, 95% CI = 0.337-0.733, p < 0.001), asthma (OR: 0.687, 95% CI = 0.540-0.876, p = 0.002), and lung cancer (OR: 0.569, 95% CI = 0.433-0.748, p < 0.001), and further indicated potential causality with pneumonia (OR: 0.817; 95% CI = 0.686-0.972, p = 0.022). No association was evident with COVID-19 (OR: 0.934, 95% CI = 0.764-1.142, p = 0.507), tuberculosis (OR: 0.597, 95% CI = 0.512-1.189, p = 0.120), or bronchiectasis (OR: 0.680, 95% CI = 0.311-1.489, p = 0.400). Reverse MR analysis suggested no reverse causal relationship between pulmonary disease and household income status, while sensitivity analysis verified the reliability of the results.
UNASSIGNED: The results revealed that the population with a higher household income tended to have a lower risk of genetic susceptibility to COPD, asthma, and lung cancer.
■对大量欧洲人进行了MR研究,使用公开可用的全基因组关联研究数据集,使用随机效应逆方差加权模型作为主要标准。同时,MR-Egger回归,加权中位数,和最大似然估计作为补充。敏感性分析,包括异质性测试和水平多效性测试,是用科克伦的Q进行的,MR-Egger截获,和MR-PRESSO测试,以确保结论的可靠性。
■较高的家庭收入倾向于降低慢性阻塞性肺疾病遗传易感性的风险(COPD,OR:0.497,95%CI=0.337-0.733,p<0.001),哮喘(OR:0.687,95%CI=0.540-0.876,p=0.002),和肺癌(OR:0.569,95%CI=0.433-0.748,p<0.001),并进一步表明与肺炎的潜在因果关系(OR:0.817;95%CI=0.686-0.972,p=0.022)。与COVID-19无明显关联(OR:0.934,95%CI=0.764-1.142,p=0.507),结核病(OR:0.597,95%CI=0.512-1.189,p=0.120),或支气管扩张(OR:0.680,95%CI=0.311-1.489,p=0.400)。反向MR分析表明肺部疾病与家庭收入状况之间没有反向因果关系,敏感性分析验证了结果的可靠性。
■结果显示,家庭收入较高的人群对COPD的遗传易感性风险较低,哮喘,还有肺癌.