PDF(Pubmed)
Abstract：
This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies - Parkinson\'s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared to healthy controls. Autoinflammatory disorders typically involve the immune system mistakenly attacking the body\'s own cells and start producing ANA. There is an increasing body of evidence that immune-mediated inflammation is a pathological feature linked to synucleinopathies. To investigate whether this could be autoimmune mediated we analyzed for ANA in the plasma of 25 MSA, 25 PD, and 17 DLB patients, along with 25 healthy controls, using the ANA HEp-2 indirect immunofluorescence antibody assay (ANA HEp-2 IFA). Contrary to initial expectations, results showed ANA HEp-2 positivity in 12% of PD, 8% of MSA patients, 18% of DLB patients, and 17% of healthy controls, indicating no increased prevalence of ANA in synucleinopathies compared to age-matched healthy individuals. Various ANA HEp-2 patterns were identified, but no specific pattern was associated with individual synucleinopathies. We conclude hereby that synucleinopathies are not associated with detectable presence of ANA in plasma.
摘要：
本研究调查了三种原发性突触核蛋白病-帕金森病（PD）中抗核抗体（ANA）的存在，多系统萎缩（MSA），和路易体痴呆（DLB），与健康对照相比。自身炎症性疾病通常涉及免疫系统错误地攻击身体自身的细胞并开始产生ANA。越来越多的证据表明免疫介导的炎症是与突触核蛋白病相关的病理特征。为了研究这是否可能是自身免疫介导的，我们分析了25MSA血浆中的ANA，25PD,和17名DLB患者，以及25个健康对照，使用ANAHEp-2间接免疫荧光抗体测定(ANAHEp-2IFA)。与最初的期望相反，结果显示ANAHEp-2在12%的PD中呈阳性，8%的MSA患者，18%的DLB患者，和17%的健康对照组，表明与年龄匹配的健康个体相比，突触核蛋白病中ANA的患病率没有增加。确定了各种ANAHEp-2模式，但没有特定模式与个体突触核蛋白病变相关。我们由此得出结论，突触核蛋白病与血浆中ANA的可检测存在无关。
