单纯疱疹病毒 1 型通过调节小胶质细胞吞噬作用和激活 NLRP3 通路加速阿尔茨海默病的进展.
Mesh : Animals NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Alzheimer Disease / pathology metabolism virology Mice Herpesvirus 1, Human Microglia / metabolism pathology virology Mice, Transgenic Phagocytosis Disease Progression Signal Transduction / physiology Humans Herpes Simplex / pathology immunology metabolism Amyloid beta-Peptides / metabolism Amyloid beta-Protein Precursor / genetics metabolism Disease Models, Animal Presenilin-1 / genetics metabolism
来 源:
DOI:10.1186/s12974-024-03166-9
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