PDF(Pubmed)
Abstract：
Although numerous ambient ionization mass spectroscopy technologies have been developed over the past 20 years to address diverse analytical circumstances, a single-ion source technique that can handle all analyte types is still lacking. Here, a wide-energy programmable microwave plasma-ionization mass spectrometry (WPMPI-MS) system is presented, through which MS analysis can achieve high coverage of substances with various characteristics by digitally regulating the microwave energy. In addition, ionization energy can be rapidly scanned using programmable waveforms, enabling the simultaneous detection of biomolecules, heavy metals, non-polar molecules, etc., in seconds. WPMPI-MS performs well in analyzing real samples, rapidly analyzing nine toxicological standards in one drop of serum, and demonstrating good quantification and liquid chromatography coupling capability. The WPMPI-MS has also been used to detect soil extracts, solid pharmaceuticals, and landfill leachate, further demonstrating its robust analytical capabilities for real samples. The prospective uses of the technology in biological and chemical analysis are extensive, and it is anticipated to emerge as a viable alternative to commercially available ion sources.
摘要：
尽管在过去的20年中已经开发了许多环境电离质谱技术来解决各种分析环境，仍然缺乏能够处理所有分析物类型的单离子源技术。这里,提出了一种宽能量可编程微波等离子体电离质谱（WPMPI-MS）系统，通过MS分析可以通过数字调节微波能量来实现具有各种特性的物质的高覆盖率。此外,可以使用可编程波形快速扫描电离能，能够同时检测生物分子，重金属,非极性分子，等。,在几秒钟内。WPMPI-MS在分析真实样品方面表现良好，快速分析一滴血清中的九种毒理学标准，并表现出良好的定量和液相色谱耦合能力。WPMPI-MS还用于检测土壤提取物，固体药物,和垃圾渗滤液，进一步证明了其对真实样品的强大分析能力。该技术在生物和化学分析中的潜在用途是广泛的，并且预计它将成为市售离子源的可行替代品。
