Abstract：
Sarcoptic mange is a debilitating disease that affects bare-nosed wombats (Vombatus ursinus). One of the drugs currently used for treatment is moxidectin, as it has a relatively high efficacy against endo and ectoparasites and side effects are uncommon in domestic species, thus it is considered a relatively safe drug to use at the recommended doses. Developing further understanding of the pharmacokinetics of moxidectin will aid in developing treatment regimens for sarcoptic mange in wombats. Here we analyzed the pharmacokinetic parameters of using 100 ml of moxidectin (5 g/l) applied topically. We found that mean peak plasma concentration was 0.50 ng/ml and half-life was 8 days. Moxidectin was excreted in scats with the mean peak concentration of 2461.43 ng/g (on a dry matter basis). Our study has provided the pharmacokinetic parameters of a commonly used treatment for sarcoptic mange in wombats. There were no adverse side effects recorded in the wombats after applying moxidectin topically. This study replicated real-world conditions using topical application on free-living wombats. The relatively low plasma concentration suggests the drug is not accumulating in the blood stream and is excreted via scats.
摘要：
Sarcopticmange是一种使人衰弱的疾病，会影响裸露的袋熊（Vombatusursinus）。目前用于治疗的药物之一是莫西丁，因为它对内寄生虫和外寄生虫有相对较高的疗效，副作用在家畜中并不常见，因此，在推荐剂量下使用它被认为是相对安全的药物。进一步了解莫昔克丁的药代动力学将有助于开发袋熊中的sarcopticmange的治疗方案。在这里，我们分析了局部使用100ml莫昔克丁（5g/l）的药代动力学参数。我们发现平均峰值血浆浓度为0.50ng/ml，半衰期为8天。莫昔克丁在粪便中排泄，平均峰值浓度为2461.43ng/g（以干物质为基础）。我们的研究提供了袋熊中常用的sarcopticmange治疗方法的药代动力学参数。局部应用莫昔克丁后，袋熊没有不良副作用。这项研究使用自由生活的袋熊的局部应用复制了现实世界的条件。相对较低的血浆浓度表明药物不会在血流中积累，而是通过粪便排出。
