Abstract：
Chemotherapy and radiotherapy are widely used in clinical practice across the globe as cancer treatments. Intrinsic or acquired chemoresistance poses a significant problem for medical practitioners and researchers, causing tumor recurrence and metastasis. The most dangerous kind of malignant brain tumor is called glioblastoma multiforme (GBM) that often recurs following surgery. The most often used medication for treating GBM is temozolomide chemotherapy; however, most patients eventually become resistant. Researchers are studying preclinical models that accurately reflect human disease and can be used to speed up drug development to overcome chemoresistance in GBM. Non-coding RNAs (ncRNAs) have been shown to be substantial in regulating tumor development and facilitating treatment resistance in several cancers, such as GBM. In this work, we mentioned the mechanisms of how different ncRNAs (microRNAs, long non-coding RNAs, circular RNAs) can regulate temozolomide chemosensitivity in GBM. We also address the role of these ncRNAs encapsulated inside secreted exosomes.
摘要：
化疗和放疗作为癌症治疗在全球范围内被广泛用于临床实践。内在或获得性化学耐药对医生和研究人员来说是一个重大问题，引起肿瘤复发和转移。最危险的恶性脑肿瘤称为多形性胶质母细胞瘤（GBM），通常在手术后复发。治疗GBM最常用的药物是替莫唑胺化疗;然而，大多数患者最终会产生抗药性。研究人员正在研究能够准确反映人类疾病的临床前模型，并可用于加快药物开发以克服GBM中的化学耐药性。非编码RNA（ncRNAs）已被证明在调节肿瘤发展和促进几种癌症的治疗抗性方面具有重要作用。比如GBM。在这项工作中,我们提到了不同ncRNAs(microRNAs，长链非编码RNA，环状RNA）可以调节GBM中的替莫唑胺化学敏感性。我们还讨论了这些包裹在分泌外泌体内部的ncRNA的作用。
