PDF(Pubmed)
Abstract：
OBJECTIVE: Reflecting the need for an effective support for the daily oral hygiene routine of patients experiencing (symptoms of) gum inflammation, a new mouthwash has been developed containing an amine + zinc lactate + fluoride system. The in vitro efficacy of this product was assessed using traditional laboratory methods, as well as novel experimentation.
METHODS: This mouthwash has been evaluated in a series of laboratory tests including two short interval kill tests (SIKTs), a 12-h (longer term) biofilm regrowth assay, a plaque glycolysis assay, and an aerobic, repeated exposure biofilm model, as well as tests for soft tissue uptake and LPS neutralization.
RESULTS: Several laboratory studies demonstrate that a mouthwash containing an amine + zinc lactate + fluoride system provides short-term and long-term antibacterial activity. While the immediate efficacy of this formula has been shown to be driven by the presence of the amine, zinc lactate provides a long-term antibacterial effect, as well as is able to inhibit bacterial metabolism.
CONCLUSIONS: This research provides the basis for understanding the mode of action of this new mouthwash formulation and explains the previously observed clinical efficacy of this formula against plaque and gingivitis.
METHODS: This mouthwash has been evaluated in a series of laboratory tests including two short interval kill tests (SIKTs), a 12-h (longer term) biofilm regrowth assay, a plaque glycolysis assay, and an aerobic, repeated exposure biofilm model, as well as tests for soft tissue uptake and LPS neutralization.
RESULTS: Several laboratory studies demonstrate that a mouthwash containing an amine + zinc lactate + fluoride system provides short-term and long-term antibacterial activity. While the immediate efficacy of this formula has been shown to be driven by the presence of the amine, zinc lactate provides a long-term antibacterial effect, as well as is able to inhibit bacterial metabolism.
CONCLUSIONS: This research provides the basis for understanding the mode of action of this new mouthwash formulation and explains the previously observed clinical efficacy of this formula against plaque and gingivitis.
摘要：
目的：反映需要有效支持患有牙龈炎症（症状）的患者的日常口腔卫生常规，一种新的漱口水已开发出含有胺+乳酸锌+氟化物系统。使用传统的实验室方法评估该产品的体外功效，以及新颖的实验。
方法：已在一系列实验室测试中对该漱口水进行了评估，包括两个短间隔杀灭测试（SIKTs），12小时（长期）生物膜再生试验，斑块糖酵解试验，和有氧运动，重复暴露生物膜模型，以及软组织摄取和LPS中和的测试。
结果：一些实验室研究表明，含有胺+乳酸锌+氟化物系统的漱口水具有短期和长期的抗菌活性。虽然该配方的直接功效已被证明是由胺的存在驱动的，乳酸锌提供了一个长期的抗菌作用，以及能够抑制细菌代谢。
结论：这项研究为了解这种新型漱口水配方的作用方式提供了基础，并解释了以前观察到的该配方对牙菌斑和牙龈炎的临床疗效。
方法：已在一系列实验室测试中对该漱口水进行了评估，包括两个短间隔杀灭测试（SIKTs），12小时（长期）生物膜再生试验，斑块糖酵解试验，和有氧运动，重复暴露生物膜模型，以及软组织摄取和LPS中和的测试。
结果：一些实验室研究表明，含有胺+乳酸锌+氟化物系统的漱口水具有短期和长期的抗菌活性。虽然该配方的直接功效已被证明是由胺的存在驱动的，乳酸锌提供了一个长期的抗菌作用，以及能够抑制细菌代谢。
结论：这项研究为了解这种新型漱口水配方的作用方式提供了基础，并解释了以前观察到的该配方对牙菌斑和牙龈炎的临床疗效。
