Abstract：
Tumors have always been a major public health concern worldwide, and attempts to look for effective treatments have never ceased. Sialic acid is known to be a crucial element for tumor development and its receptors are highly expressed on tumor-associated immune cells, which perform significant roles in establishing the immunosuppressive tumor microenvironment and further boosting tumorigenesis, progression, and metastasis. Obviously, it is essential to consider sophisticated crosstalk between tumors, the immune system, and preparations, and understand the links between pharmaceutics and immunology. Sialic acid-based chemoimmunotherapy enables active targeting drug delivery via mediating the recognition between the sialic acid-modified nano-drug delivery system represented by liposomes and sialic acid-binding receptors on tumor-associated immune cells, which inhibit their activity and utilize their homing ability to deliver drugs. Such a \"Trojan horse\" strategy has remarkably improved the shortcomings of traditional passive targeting treatments, unexpectedly promoted tumor shedding, and persistently induced robust immunological memory, thus highlighting its prospective application potential for targeting various tumors. Herein, we review recent advances in sialic acid-based active targeting chemoimmunotherapy to promote tumor shedding, summarize the current viewpoints on the tumor shedding mechanism, especially the formation of durable immunological memory, and analyze the challenges and opportunities of this attractive approach.
摘要：
肿瘤一直是世界范围内主要的公共卫生问题。寻找有效治疗方法的尝试从未停止过。已知唾液酸是肿瘤发展的关键因素,其受体在肿瘤相关免疫细胞上高表达,在建立免疫抑制肿瘤微环境和进一步促进肿瘤发生方面发挥重要作用，programming,和转移。显然,必须考虑肿瘤之间复杂的串扰，免疫系统,和准备工作，了解药剂学和免疫学之间的联系。基于唾液酸的化学免疫疗法通过介导由脂质体代表的唾液酸修饰的纳米药物递送系统与肿瘤相关免疫细胞上的唾液酸结合受体之间的识别来实现主动靶向药物递送。抑制它们的活性并利用它们的归巢能力来输送药物。这种"特洛伊木马"策略显著改善了传统被动靶向治疗的缺点,意外促进肿瘤脱落，持续诱导强大的免疫记忆，从而突出了其靶向各种肿瘤的未来应用潜力。在这里，我们回顾了以唾液酸为基础的主动靶向化学免疫疗法促进肿瘤脱落的最新进展，总结目前关于肿瘤脱落机制的观点，尤其是持久免疫记忆的形成，并分析这种有吸引力的方法的挑战和机遇。
