PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to systematically assess physical exercise-related symptoms of post-acute sequelae of SARS-CoV-2 infection (PASC or long COVID) in coronavirus disease 2019 (COVID-19) survivors.
UNASSIGNED: Eight databases were systematically searched on March 03, 2024. Original studies that compared physical exercise-related parameters measured by exercise testing between COVID-19 survivors who recovered from SARS-CoV-2 infection over 3 months and non-COVID-19 controls were included. A random-effects model was utilized to determine the mean differences (MDs) or standardized MDs in the meta-analysis.
UNASSIGNED: A total of 40 studies with 6241 COVID-19 survivors were included. The 6-min walk test, maximal oxygen consumption (VO2max), and anaerobic threshold were impaired in COVID-19 survivors 3 months post-infection compared with non-COVID-19 controls in exercise testing, while VO2 were comparable between the two groups at rest. In contrast, no differences were observed in SpO2, heart rate, blood pressure, fatigue, and dyspnea between COVID-19 survivors and non-COVID-19 controls in exercise testing.
UNASSIGNED: The findings suggest an underestimation of the manifestations of PASC. COVID-19 survivors also harbor physical exercise-related symptoms of PASC that can be determined by the exercise testing and are distinct from those observed at rest. Exercise testing should be included while evaluating the symptoms of PASC in COVID-19 survivors.
UNASSIGNED: Eight databases were systematically searched on March 03, 2024. Original studies that compared physical exercise-related parameters measured by exercise testing between COVID-19 survivors who recovered from SARS-CoV-2 infection over 3 months and non-COVID-19 controls were included. A random-effects model was utilized to determine the mean differences (MDs) or standardized MDs in the meta-analysis.
UNASSIGNED: A total of 40 studies with 6241 COVID-19 survivors were included. The 6-min walk test, maximal oxygen consumption (VO2max), and anaerobic threshold were impaired in COVID-19 survivors 3 months post-infection compared with non-COVID-19 controls in exercise testing, while VO2 were comparable between the two groups at rest. In contrast, no differences were observed in SpO2, heart rate, blood pressure, fatigue, and dyspnea between COVID-19 survivors and non-COVID-19 controls in exercise testing.
UNASSIGNED: The findings suggest an underestimation of the manifestations of PASC. COVID-19 survivors also harbor physical exercise-related symptoms of PASC that can be determined by the exercise testing and are distinct from those observed at rest. Exercise testing should be included while evaluating the symptoms of PASC in COVID-19 survivors.
摘要：
■这项研究旨在系统地评估2019年冠状病毒病（COVID-19）幸存者SARS-CoV-2感染（PASC或长COVID）急性后遗症的体育锻炼相关症状。
■2024年3月3日系统地搜索了八个数据库。包括原始研究，这些研究比较了通过运动测试在3个月内从SARS-CoV-2感染中恢复的COVID-19幸存者与非COVID-19对照组之间的体育锻炼相关参数。使用随机效应模型来确定荟萃分析中的平均差异（MD）或标准化MD。
■共纳入40项研究，6241例COVID-19幸存者。6分钟步行测试，最大耗氧量（VO2max），在运动测试中，与非COVID-19对照组相比，COVID-19幸存者感染后3个月的无氧阈值受损，而静息时两组的VO2相当。相比之下,在SpO2，心率，血压,疲劳,运动测试中COVID-19幸存者和非COVID-19对照组之间的呼吸困难。
■研究结果表明，PASC的表现被低估了。COVID-19幸存者还存在PASC的体育锻炼相关症状，这些症状可以通过运动测试确定，与静息时观察到的症状不同。在评估COVID-19幸存者的PASC症状时，应包括运动测试。
■2024年3月3日系统地搜索了八个数据库。包括原始研究，这些研究比较了通过运动测试在3个月内从SARS-CoV-2感染中恢复的COVID-19幸存者与非COVID-19对照组之间的体育锻炼相关参数。使用随机效应模型来确定荟萃分析中的平均差异（MD）或标准化MD。
■共纳入40项研究，6241例COVID-19幸存者。6分钟步行测试，最大耗氧量（VO2max），在运动测试中，与非COVID-19对照组相比，COVID-19幸存者感染后3个月的无氧阈值受损，而静息时两组的VO2相当。相比之下,在SpO2，心率，血压,疲劳,运动测试中COVID-19幸存者和非COVID-19对照组之间的呼吸困难。
■研究结果表明，PASC的表现被低估了。COVID-19幸存者还存在PASC的体育锻炼相关症状，这些症状可以通过运动测试确定，与静息时观察到的症状不同。在评估COVID-19幸存者的PASC症状时，应包括运动测试。
